L24 - Rheumatic Disease II Flashcards
(18 cards)
fybromyalgia
- syndrome (not a disease!) characterized by widespread body pain
- lack of inflammation means that it is futile to treat with anti-inflammatory agents
- does not exclude other diseases
non-inflammatory arthritis characteristics
- Pain: worse in PM
- Stiffness: not frequent
- Redness: absent
- Swelling: yes-bony
inflammatory arthritis characteristics
- Pain: worse in AM
- Stiffness: AM
- Redness: present
- Swelling: yes-soft
treatments for osteoarthritis
- exercise and weight loss
- acetaminophen and NSAIDs
- synvisc (hylan A and B polymers)
- joint replacement
- No evidence supporting biological therapy
measures to track response to lupus therapy
anti-DNA antibodies and complement levels (ANA levels are NOT useful)
drugs for RA
Anti-Inflammatory Drugs
- aspirin
- NSAIDs
- steroids (prednisone)
Disease-modifying Anti-Rheumatic Drugs (DMARDs)
- methotrexate
- hydroxychloroquine
- azathioprine
- TNF antagonists
- IL-6R antagonists
- IL-1R antagonists
- anti-B-cell antibodies
- blockade of B7/CD28 signaling
drugs for SLE
- sunscreen
- NSAIDs
- glucocorticoids
- antimalarials (hydroxychloroquine)
- immunosuppressives (methotrexate, azathioprine)
- antibodies targeting B-cells
- syndrome (not a disease!) characterized by widespread body pain
- lack of inflammation means that it is futile to treat with anti-inflammatory agents
- does not exclude other diseases
fybromyalgia
- Pain: worse in PM
- Stiffness: not frequent
- Redness: absent
- Swelling: yes-bony
non-inflammatory arthritis characteristics
- Pain: worse in AM
- Stiffness: AM
- Redness: present
- Swelling: yes-soft
inflammatory arthritis characteristics
“-cept”
drug that fuses to the FcR of IgG1
“-mab”
drug that serves as a monoclonal antibody
“-ximab”
drug that serves as a chimeric antibody
“-zumab”
drug that serves as a humanized antibody
drug that fuses to the FcR of IgG1
“-cept”
drug that serves as a monoclonal antibody
“-mab”
drug that serves as a chimeric antibody
“-ximab”
drug that serves as a humanized antibody
“-zumab”
