L26: Hepatitis B

Question 1

Hep B and C arise from?

Answer 1

the bloodstream

Question 2

Hep A source of infection

Answer 2

faeces

Question 3

How is Hep B transmitted

Answer 3

1. mother to child
2. child to child
3. persistent infection following acquisition in infancy ot childhood

Question 4

Lab diagnostics for Hep

Answer 4

• microscopy
• culture (agar or borth)
• chemical test

Question 5

What is searched for in Hep B diagnosis

Answer 5

Hepatitis B surface antigen (HBsAg)

Question 6

Explain the structure of Hep B

Answer 6

• outer envelope: HBsAg
• central shell: core angtigen: HBcAg
• DNA inside central shell

Question 7

What is detected in the blood of Hep B infections

Answer 7

HBsAg clumps - forms spheres and tubuöes

Question 8

What determines HVC infectivity

Answer 8

HBeAg

Question 9

HBV concentrations in blood

Answer 9

high concentration of HBeAg - more infectious than low concentration of HBeAg

Question 10

How do infected cells get removed

Answer 10

cytotoxic killing

Question 11

How do infected cells get removed

Answer 11

cytotoxic killing

Question 12

HBV infection in adults vs infants

Answer 12

• infants, immune system not fully developed - infection consequences later in life - continued liver damage over decades
• adult, infection, symptomatic, cleared, immune bc make HBsAb