L4 - Neurulation Flashcards Preview

Developmental Neurobiology > L4 - Neurulation > Flashcards

Flashcards in L4 - Neurulation Deck (5)
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1
Q

Apical basal polarity

A

Neural plate neuroepithelial cells are polarised
A band of F actin is at the apical side
- If this pulls tight, the cells are constricted and change shape

2
Q

During neurulation many molecules interact with

A

F-actin to make it constrict

They are also differently distributed to basal or apical edges

3
Q

Changes in cell shape are signalled by?

A

Folate leading to changes in tissue shape

4
Q

Deficiencies in folate

A

During neurulation a topologically flat surface pinches off to form the CNS
Deficiencies in folate can cause failure to close that tube - spina bifida

5
Q

Xenopus studies on neurulation

A

They have externally visible developing embryos
Key role of folate receptors at apical surface of the neural plate—where it interacts with cytoskeletal and adherens junction components