L75: Parathyroid & Ca regulation Flashcards Preview

FHB - Endocrinology (by Richie) > L75: Parathyroid & Ca regulation > Flashcards

Flashcards in L75: Parathyroid & Ca regulation Deck (44)
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1

Osteoprotegerin (OPG)

decoy for RANKL. It binds RANKL.

2

Osteoprotegerin

?

3

RANKL

?

4

M-CSF

?

5

What is the normal range of calcium (normal)?

2.2-2.5mM (tightly regulated)

6

Albumin levels

good indicator of free Ca2+ availability

7

2 regulators of Ca2+

Vitamin D PTH

8

What cells secrete PTH

Chief cells

9

These cells increase with age and chronic kidney disease. No known function.

Oxyphil cells

10

PTHrP

?

11

PTH1R

?

12

PTH2R

?

13

PTH targets

bone and kidney

14

Net effect of PTH

increase plasma Ca, decrease plasma Pi

15

Nucleation

Process of mineralizing/hardening bone...via osteoblasts

16

PTH receptors are located on osteoblasts or osteoclasts?

Osteoblasts

17

PTH stimulates osteoblasts to make

M-CSF. Causes stem cells to differentiate into osteoclasts

18

What ligand activates mature osteoclasts?

RANKL

19

What makes RANKL?

Osteoblasts

20

What does cortisol do to OPG?

Inhibits it. This allows excess RANKL to stimulate osteoclasts, making more bone breakdown than normal.

21

2 effects of PTH on kidney

?

22

Calcium sensing receptor

?

23

Where is CaSR located?

Kidney, Chief cells, C-cells

24

Direct and indirect actions of CaSR

?

25

Direct and indirect actions of 1,25 Vitamin D

?

26

Does D3 have a high affinity for vitamin D receptor?

No

27

3 targets of VitD

Bone gut kidney

28

Calbindin

?

29

Primary vs. secondary hyperparathyroidism

?

30

Chvostek sign

Twitching of facial muscles in response to tapping CNVII