Flashcards in Learnly Deck (21):
The ____ innervates the posterior third of the tongue, the vallecula, and the anterior surface of the epiglottis, and also innervates the roof of the pharynx, the tonsils, and the undersurface of the soft palate
What does the glossopharyngeal n. innervate?
-posterior third of the tongue
-vallecula, and the anterior surface of the epiglottis
-roof of the pharynx, the tonsils, and undersurface of the soft palate
What innervates the anterior two-thirds of the tongue?
lingual n. (part of mandibular division of CNV)
Sensory innervation of the vocal cords and the trachea is provided by the ____.
recurrent laryngeal n,, a branch of the vagus (X)
What does the recurrent laryngeal n. innervate?
sensory innervation of vocal cords/trachea
_____ (narcotic) is hydrophilic, thus when it is administered intrathecally, it persists in the cerebrospinal circulation for many hours
If ____ (narc) were given intrathecally, it would quickly bind near the site of administration to primarily affect lumbosacral nerve roots
define first-order kinetics
rate of elimination is proportional to the concentration of the drug
Name a drug where volume of distribution exceeds volume of subject.
fentanyl (and other fat soluble drugs)
___ exists only in ionized state, and ____ exists in a neutral form.
glyco = ionized = doesn't cross BBB easily
atropine = neutral = crosses BBB
Redistribution into the ____ compartment is most responsible for the rapid wake-up after a single bolus dose of propofol.
Propofol distribution into ___ compartment is responsible for the sedative-hypnotic effect
Real name of propofol?
What makes up propofol?
1% emulsion containing:
- 10% soybean oil
- 2.25% glycerol
- 1.2% purified egg phosphatide
- preservative disodium edentate 0.005% with Na hydroxide
MOA of propofol
activating GABA-A receptors in the CNS
How is propofol eliminated?
Where is propofol metabolized?
The two major plasma proteins are ____ and ____.
2. alpha-1-acid glycoprotein
What is partition coefficient?
ratio of concentrations of a drug in a mixture of two interconnecting, but unmixable phases at equilibrium
The ___ of a drug is defined as the pH at which half the drug is in its ionized form and half in its non-ionized form.