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Flashcards in Learnly Deck (21):
1

The ____ innervates the posterior third of the tongue, the vallecula, and the anterior surface of the epiglottis, and also innervates the roof of the pharynx, the tonsils, and the undersurface of the soft palate

glossopharyngeal n.

2

What does the glossopharyngeal n. innervate?

-posterior third of the tongue
-vallecula, and the anterior surface of the epiglottis
-roof of the pharynx, the tonsils, and undersurface of the soft palate

3

What innervates the anterior two-thirds of the tongue?

lingual n. (part of mandibular division of CNV)

4

Sensory innervation of the vocal cords and the trachea is provided by the ____.

recurrent laryngeal n,, a branch of the vagus (X)

5

What does the recurrent laryngeal n. innervate?

sensory innervation of vocal cords/trachea

6

_____ (narcotic) is hydrophilic, thus when it is administered intrathecally, it persists in the cerebrospinal circulation for many hours

morphine

7

If ____ (narc) were given intrathecally, it would quickly bind near the site of administration to primarily affect lumbosacral nerve roots

fentanyl

8

define first-order kinetics

rate of elimination is proportional to the concentration of the drug

9

Name a drug where volume of distribution exceeds volume of subject.

fentanyl (and other fat soluble drugs)

10

___ exists only in ionized state, and ____ exists in a neutral form.

glyco = ionized = doesn't cross BBB easily
atropine = neutral = crosses BBB

11

Redistribution into the ____ compartment is most responsible for the rapid wake-up after a single bolus dose of propofol.

intermediate compartment

12

Propofol distribution into ___ compartment is responsible for the sedative-hypnotic effect

vessel-rich compartment

13

Real name of propofol?

2,6-diisopropylphenol

14

What makes up propofol?

1% emulsion containing:
- 10% soybean oil
- 2.25% glycerol
- 1.2% purified egg phosphatide
- preservative disodium edentate 0.005% with Na hydroxide

15

MOA of propofol

activating GABA-A receptors in the CNS

16

How is propofol eliminated?

kidneys

17

Where is propofol metabolized?

liver

18

The two major plasma proteins are ____ and ____.

1. albumin
2. alpha-1-acid glycoprotein

19

What is partition coefficient?

ratio of concentrations of a drug in a mixture of two interconnecting, but unmixable phases at equilibrium

20

The ___ of a drug is defined as the pH at which half the drug is in its ionized form and half in its non-ionized form.

pKa

21

Most local anesthetics are produced as weak ___.

weak bases