LEC 1 - Intro to Haematology Flashcards Preview

HAEMATOLOGY > LEC 1 - Intro to Haematology > Flashcards

Flashcards in LEC 1 - Intro to Haematology Deck (18):
1

Define myelopoiesis?

Production of bone marrow

2

How often to RBC last for?

how often do neutrophils last for?

RBC - 120 days

Neutrophils 6-10 hours

3

In the foetus where does haemopoiesis start?

What day does RBC production move to the foetal liver?

Aorto-Gonado-Mesenephros @ day 27

Day 40

4

When do you get lymphocytosis?

Lymphocytosis - incr number of WBC

Occurs post virus e.g. glandular fever (infectious mononucleosis)

5

When do you get neutropenia?

If you take immunosuppressants (e.g. steroids)

6

When do you get eosinophilia?

Parasitic infections/ allergies

7

When do you get basophilic?

Chronic myeloid Leykaemia

Or other myeloproliferative neoplasms

8

What is plastmacytosis?

Incr number of B cells

9

What is MCV and MCH

MCV - mean cell volume (cell size)

MCH - Mean cell Hb. How chromatic it is

10

What makes a test sensitive?

When a test can detect a true false negative (correctly i.d. abnormal test results)

11

What makes a test specific?

How well a test is able to exclude false positives

12

What conditions could cause microcytic hypo chromic blood film?

Anaemia
Iron deficiency
thalassaemia
Lead poisoning

13

What conditions could cause normocytic normochromatic blood films? Have hypersegmented neutrophils + oval macrocytes

Anaemia of chronic disease
Blood loss
Renal disease
Bone marrow failure
Haemolytic anaemia

14

What causes macrocytic blood film?

B12/ folate deficiency
Alcohol
Liver disease
Aplastic anaemia

15

What is myelodysplasia?

What lineage does it affect?

What is it caused by?

Group of diseases that affect normal blood cell production

Affects myeloid lineage

Caused by mutated stem cell producing clones of abnormal cell.
Causes all cells on myeloid side to be malignant

16

What is megaloblastic erythropoiesis?

What causes it?

DNA synthesis inhibited during RBC production

B12/ folate deficiency
Liver disease
Alcohol
Hypothyroidism
Stress (recovering from blood loss

17

What are the lab features of myelodysplasia (MDS)

Anaemia
Neutropenia
Thrombocytopenia

18

What is MDS-SQ syndrome?

What drugs can treat this?

Partial loss of q arm on chromosome S. Type of MDS

Causes myelodysplasia

Lenalidomide
Azacytine
Immunosuppressants
Chemo