lec 3: permeation Flashcards
(28 cards)
WHAT ARE BARRIERS TO DRUG MOVEMENT
WHAT ARE CHARACTERISTICS OF BIO MEMBRANES
WHAT IS POW
EPITHELEAL CELLS QUALITIES? SO DRUGS MUST…..
BBB QUALITY? SO DRUGS MUST…
WHERE IN THE BBB ARE PERMEABLE TO DRUGS
WHY IS BBB AN ISSUE IN DRUG TARGETING
WHAT HAPPENS AT THE PALCENTA WRT DRUGS/ WHAT CAN CROSS? WHAT DETERMINES CROSSING?
WHAT ARE TRANSPORTERS RESPONSIBLE FOR?
CONTRAST PASSIVE VS FACILITATED DIFFUSION
CONTRAST PRIMARY ACTIVE TRANSPORT VS SECONDARY ACTIVE TRANSPORT
WHERE ARE COMMON SITES OF DRUG TRANSPORT
DESCRIBE POLARIZATION OF ENTEROCYTES VS RENAL CELLS VS HEPATOCYTES VS BBB
WHAT ARE SOLUTE CARRIER TRANSPORTERS? LOCALIZATION? WHAT ARE THE TYPES
WHAT FAMILY ARE OATS IN/ HOW MANY? WHAT TYPE? SUBSTRATES? DRUGS THAT USE THEM?
WHAT FAMILY ARE OCTS FROM? HOW MANY? LOCALIZATION? SUBSTRATES? DRUGS USING THEM?
WHAT ARE OCTNS? FAMILY? TYPES? LOCALIZATION? DEFICIENCIES LEAD TO…?
WHAT ARE OATPS? FAMILY? NUMBER? SUBSTRATES? DRUGS USING THEM?
WHAT ARE ABC TRANSPORTERS?
WHAT ARE MDR1S? SUBSTRATES? LOCALIZED? ROLES?
WHAT ARE MRP1? SUBS? LOCATION? ROLES?
WHAT ARE MRP2? SUBS? LOCATION? ROLES?>
WHAT ARE BCRP? SUBS? LOCATED? ROLES?
WHAT IS THE PGP? HOW DO THINGS BIND? WHAT HAPPENS TO THE SUBS?
