LEC 4 - Aspergillus + Dermatophytes Flashcards
Aspergillus species
Fumigatus
– and –
Flavus
What does flavus do pathologically?
Hepatotoxicity
Symptoms of A. Fumigatus: Cats/Dog
Sinonasal discharge
Symptoms of A. Fumigatus: Birds
Air saculitis
Symptoms of A. Fumigatus: Equine
Guttural pouch mycosis
How does Aspergillus cause disease in an animal?
Respiratory infection due to spore inhalation
Tissue invasion possible
What is the major virulence factor in Aspergillus?
Gliotoxin
Describe: Gliotoxin
Mucocillary apparatus
– and –
Immune evasion
What are ways that you can diagnose Aspergillus?
Fungal Culture
Fungal serology
Rhinoscopy/biopsy/histology
What fungal culture is used to grow aspergillus?
Sab dex
What color is a colony of aspergillus on fungal culture?
Blue/green to black/light tan
What can aspergillus from a fungal culture be stained with?
Lactophenol cotton blue
What are the four basic kinds of fungal cultures?
Sabaroud dextrose
Potato dextrose
Birdseed agar
DTM
How can you tell penicillin apart from aspergillus?
Branching in the hyphae
Systemic treatment: Aspergillus
Azoles
Topical treatment: Aspergillus
Azoles
Trephination
What are the two species of Microsporum spp?
Canis
– and –
Gypseum
What are the two species of Trichophyton spp.?
Mentagrophytes
– and –
Verrucosum
Describe: Microsporum
Spindle shaped
Thick walled
Rough
Describe: Trichophyton
Cigar shaped macroconidium
Smooth, thin walled
What type of trichophyton attacks food animals?
T. Verucosum
Describe T. Verucosum
Chain chlamydospores
What are the clinical signs of a dermatophyte infection?
Focal/Multifocal alopecia w/ scaling
Inflammatory ring
What happens to Persian cats that have a dermatophyte infection?
Pseudomycetomas
