Lecture 12: Nucleotide Metabolism Flashcards Preview

Molecular And Cellular Mechanisms (MCM) > Lecture 12: Nucleotide Metabolism > Flashcards

Flashcards in Lecture 12: Nucleotide Metabolism Deck (18):
1

What is a nucleoside?

Base + sugar

2

What is a nucleotide?

Base + sugar + phosphate

3

Purines have ___ ring (s)

2

4

Pyrimidines have ___ ring (s)

1

5

What are the purine bases?

PURE AS GOLD

Adenine, Guanine

6

What are they pyrimidine bases?

CUT THE PY

Cytosine, Uracil, Thymine

7

What are the major enzymes involved in De Novo synthesis of purine nucleotides?

-PRPP synthetase
-Glutamine: phosphoribosyl pyrophosphate amidotransferase
-IMP dehydrogenase

8

What is a major anticancer agent used on the purine nuelcotide synthesis?

Methotrexate

9

What does methotrexate inhibit?

DHRF

10

What is interesting about structure of methotrexate?

SIMILAR TO FOLIC ACID; acts as a competitive inhibitor of many enzymes

11

What is the mechanism of Sulfa drugs?

Disrupt DNA replication selectively in bacteria

12

What is an Anticancer agent?

5-fluorouracil

13

What is the mechanism of 5-fluorouracil?

inhibits THYMIDYLATE SYNTHASE, stops the production of DNA

14

What is the major regulatory point in pyrimidine synthesis?

-Carbamoyl phosphate synthetase

15

What is Acyclovir?

Antiviral agent

16

What is the mechanism of Acyclovir?

DNA polymerase blocked by false nucleotide, assemble of DNA stops

17

What is GOUT?

Intensely painful and inflamed joints, metatarsal pharangeal joint, disease of wealthy

18

What is Lesch-Nyhan Syndrome?

-Defect in HGPRT enzyme in purine salvage pathway
-Overproduction of uric acid
-Pts have hyperuricemia
-Kidney stones, poor muscle control, mental retardation and self mutilation