Flashcards in Lecture 12: Nucleotide Metabolism Deck (18):
What is a nucleoside?
Base + sugar
What is a nucleotide?
Base + sugar + phosphate
Purines have ___ ring (s)
Pyrimidines have ___ ring (s)
What are the purine bases?
PURE AS GOLD
What are they pyrimidine bases?
CUT THE PY
Cytosine, Uracil, Thymine
What are the major enzymes involved in De Novo synthesis of purine nucleotides?
-Glutamine: phosphoribosyl pyrophosphate amidotransferase
What is a major anticancer agent used on the purine nuelcotide synthesis?
What does methotrexate inhibit?
What is interesting about structure of methotrexate?
SIMILAR TO FOLIC ACID; acts as a competitive inhibitor of many enzymes
What is the mechanism of Sulfa drugs?
Disrupt DNA replication selectively in bacteria
What is an Anticancer agent?
What is the mechanism of 5-fluorouracil?
inhibits THYMIDYLATE SYNTHASE, stops the production of DNA
What is the major regulatory point in pyrimidine synthesis?
-Carbamoyl phosphate synthetase
What is Acyclovir?
What is the mechanism of Acyclovir?
DNA polymerase blocked by false nucleotide, assemble of DNA stops
What is GOUT?
Intensely painful and inflamed joints, metatarsal pharangeal joint, disease of wealthy