Lecture 18 - Lung Development and Surfactant Flashcards Preview

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Flashcards in Lecture 18 - Lung Development and Surfactant Deck (15):
1

Embryonic period events?

Day 26 - wk7: ventral outpouching, series of branching forming lung bud up to segmental bronchi

2

Embryonic period risks?

fistula

3

Pseudoglandular Period Events?

5-17wk: continues branching up to terminal bronchioles

4

Canalicular period events?

16-25wk: alveolar duct formation,

5

Saccular Period Events?

24wk-postnatal: type II alveolar cells formed and produce surfactant

6

Alveolar phase?

Late fetal -> 8yr: alveolar maturation and lining formation

7

Hydrophilic surfactant proteins?

SP-A (reduce surface tension) and D: synthesis and host defence

8

Hydrophobic surfactant proteins?

SP-B (myelin formation) and C: formation and stabiliation of the phospholipid monolayer

9

Phospholipid monolayer formation?

lamellar body degraded into tubular myelin by SPA SPA and Ca, SPA B and C form layer

10

Cells moderating phospholipid turnover?

type II cells, extracellular enzymes, macrophages

11

Compliance definition?

degree to which lung will distend per unit chang in pressure (change in V/ Palv-Pip)

12

Factors afecting compliance?

elasticity of lung tissue, surface tension of air liquid interface at alveoli

13

Law of Laplace?

r's are equal in sphere, therefor P=2T/r

14

Fluid Balance?

surfactant reduces tendency for fluid to be sucked into airspace

15

Host Defence?

surface tension gradients move matter out of alveoli towards ciliated regions, SP-A and D bind pathogen to promote phagocytosis