Lecture 18 (SMH) Respiratory Distress Syndrome Flashcards Preview

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Flashcards in Lecture 18 (SMH) Respiratory Distress Syndrome Deck (16):
1

clinical presentation of RDS in neonates:
____ muscle use; ______, ____pnea, retractions, cyanosis

accessory, grunting, tachypnea

2

Pulmonary surfactant is a mixture of ____ and ____

lecithin, sphingomyelin

3

when does surfactant synthesis typically begin? When are mature levels typically achieved? What ratio of lecithin to sphingomyelin indicates maturity?

26 weeks, 35 weeks;
2.0

4

Besides prematurity, 2 risk factors mentioned in FA that increase risk:
mechanism of each:

maternal diabetes. fetal insulin inhibits surfactant production;

C-section: decreased glucocorticoids from fetus = decreased surfactant production

5

type 2 alveolar cells are present by ___ weeks

20

6

most important lecithin in surfactant:

phosphatidylcholine

7

surfactant is synthesied in the ______ of type 2 cells, packaged by the ____, and stored as ____

smooth ER, golgi, lamellar bodies

8

circulating ____ stimulate surfactant secretion during labor and birth. _____ after birth stimulates further secretion

catecholamines;
lung distension

9

surfactant reduces ____ by displacing ______ on the alveolar surface

surface tension, water molecules

10

Law of laplace:

collapsing pressure = (2*surface tension)/radius

11

are larger or smaller alveoli harder to keep open?

smaller

12

is respiratory disress syndrome a problem with synthesis or secretion of surfactant?

secretion

13

RDS is associated with development of ____ membranes due to leakage of ____

hyaline, protein

14

what does RDS look like on CXR?

alveolar collapse, ground glass appearance of lung fields

15

treatment:
maternal ____ before birth, _____ for the infant

steroids;
artificial surfactant

16

persistently low Oxygen tension in infants increases the risk of what heart anomly?

PDA