lecture 3 biochemistry (week 2)

Question 1

what is protein lipidation diversity?

Answer 1

lipidation modification can affect the activity of the protein and gives protein distinct membrane affinities to target them to organelles and the plasma membrane

Question 2

what are the common intracellular protein lipid modifications?

Answer 2

s-palmitoylation - fatty acid palmitate - 10% of human proteome is susceptible

n-myristoylation - fatty acid myristate - >100 human proteins n-myristoylated

farnesylation - isoprenoid farnesyl - ~ 2% of all proteins are prenylated