Lecture 3: Definition of Tubular Processes (Bolser) Flashcards Preview

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Flashcards in Lecture 3: Definition of Tubular Processes (Bolser) Deck (16)
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1
Q

define filtration

A

process by which water and solutes in the blood leave the vascular system thru filtration barrier and enter Bowman’s capsule

2
Q

define secretion

A

process by which moving substances into the tubular lumen from the cytosol of epithelial cells that form the walls of the nephron

3
Q

define reabsorption

A

the process of moving substances from the lumen across the epithelial layer into the surrounding interstitium.

4
Q

define excretion

A

exit of the substance from the body

5
Q

tubular transport maximum (Tm)

A

the maximum amount of a substance that can be reabsorbed or secreted by tubules.

6
Q

what is the excretion rate formula? (it determines the amount excreted)

A
excretion rate (mg/min) = U x V
U = concentration in urine
V = urine flow rate
7
Q

what is the formula for filtered load? (it determines the amount filtered)

A
filtered load (mg/min) = P x GFR
P = concentration in plasma
8
Q

what is excretion equal to?

A

the filtration for a substance that is neither secreted nor reabsorbed. Inulin is the perfect example of this substance

9
Q

what substance is filtered and neither secreted nor reabsorbed?

A

inulin

10
Q

if a substance
amount excreted < amount filtered
then what happened to that substance?

A

then it has been reabsorbed

11
Q

what are examples of reabsorbed substances?

A

water, Na, Cl, HCO3, K, organic solutes (like sugars, amino acids, etc)

12
Q

what is the formula for the amount reabsorbed?

A

amount reabsorbed = amount filtered - amount excreted

13
Q

if a substance
amount excreted > amount filtered
then what happened to that substance?

A

then the substance has been secreted

14
Q

what is the formula for the amount secreted?

A

amount secreted = amount excreted - amount filtered

15
Q

what are examples of secreted substances?

A

K, H, NH3, organic acids and bases (like uric acid, PAH, drugs, etc)

16
Q

what is splay?

A

it is a manifestation of the fact that nephrons have a range of tubular maximum. some nephrons have lower tubular maximums than the average and they will start leaking substances into urine earlier than other nephrons.

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