Lecture 32: Development of Head and Neck I Flashcards Preview

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Flashcards in Lecture 32: Development of Head and Neck I Deck (23):
1

What cells generally gives rise to structures in the craniofacial region?

Neural crest cells

2

Name the early primordia for the facial region

Frontonasal prominence, ectodermal nasal placodes, maxillary and mandibular processes

3

What is the pharyngeal arch tissue derived from mesoderm of somitomeres?

Musculature

4

What is responsible for pharyngeal arch mesenchyme (except for musculature)?

Neural crest

5

Expression of what group of genes is responsible for segmentation of cranial neural tube?

Hox genes

6

What signals the prepatterning of cranial ectoderm?

FGF-8

7

What is responsible for patterning endoderm of the first pharyngeal pouch?

Otx2

8

What is responsible for patterning the endoderm of pharyngeal pouches 2-4?

Retinoic acid

9

What group of genes heavily influence dorsoventral patterning of pharyngeal arches?

Dlx genes

10

The frontonasal ectodermal zone is induced by Shh from which area?

A. Forebrain
B. Midbrain
C. Hindbrain
D. Pharyngeal arches

A. Forebrain

11

What is the primary function of the FGF-8/Shh gradient in the frontonasal ectodermal zone?

Shaping of the tip of the snout

12

What are the primordia of the face?

Frontonasal prominence, nasomedial processes, nasolateral processes

13

What are the primordia for the jaws?

Maxillary processes, Mandibular processes, Meckel's cartilage

14

What is responsible for subdivision of the first pharyngeal arch into upper and lower jaw primordia?

Endothelin-1

15

What are the derivatives of Meckel's cartilage?

Articular and Quadrate cartilages

16

What is Meckel's cartilage derived from?

Neural crest

17

What does the quadrate bone become in mammals?

Incus

18

What does the articular bone become in mammals?

Malleus

19

Expression of what gene is involved in the formation of the temporomandibular joint in mammals?

Barx-1

20

What are the primordia for the palate?

Unpaired median palatine process (premaxilla), paired lateral palatine processes (secondary plate)

21

Hypoplasia of the mandible and facial bones is commonly associated with an autosomal dominant condition involving the TCOF1 gene. In this condition, there is a reduced population of neural crest cells in the 1st pharyngeal arch. This condition is associated with which of the following anomalies?

A. Treacher-Collins Syndrome
B. Waardenburg Syndrome
C. Ankyloglossia
D. DiGeorge Syndrome

A. Treacher-Collins Syndrome

22

Which of the following is derived from Rathke’s pouch?

A. Thyroid
B. Diencephalon
C. Adenohypophysis
D. Olfactory epithelium

C. Adenohypophysis

23

The auditory tube is a derivative of which pharyngeal pouch?

First pharyngeal pouch