Lecture 34 - Social media, crowd source funding monoaminergic neurons. Flashcards Preview

Frontiers of Biomedicine > Lecture 34 - Social media, crowd source funding monoaminergic neurons. > Flashcards

Flashcards in Lecture 34 - Social media, crowd source funding monoaminergic neurons. Deck (9):
1

what are the ways of investigating the specific function of a brain nuclei or of sub-populations of neurons within a specific nuclei
'

Lesion brain regions (traditional) -
take out a region and look at effects.
But can damage other fibres of passage

Cannulation
-reversible
-versatile
- rod into the brain in which molecules can be delivered
- difficult to assess 'normal behaviour with chronic treatment
- don't know how far the drug is going though...

Viral vectors
- region and cell type specific
-versatile
-affected cells easily identifiable

2

What is a modified virus?

modified virus

- ability to replicate is inhibited
- selected because of low immnogenicity (wo't cause inflammation)

specifically packaged genetic material

wide range of applications
(gene therapy, reasesrch)

3

What can be put in a viral vector?

Genes
-proteins
aogist
antioxidants
promotors

4

What can be done with a viral vector?

Mapping

chronic receptor (agonist or antagonist)

modulation

gene silencing

functional modulation

parmacogenetics
- put in receptor that are only activated by designer drugs (DREADDs)
- can look at parameters of what happens when activated

Optogenetics
- very fast activation
- stimulated by LASER
- can see acute behavioural responses (anger)

5

What is scientific advocacy?

Australian acedemy of science - lobby groups

6

What is science communication?

visiting schools,community groups

blogs

podcasts/radio/TV

articles for the public

7

What is science activism?

Facebook, twitter

interactive - a conversation rather than a lecture

collaborative

8

Why bother with social media?

passionate about a scientific topic

understand the community views on a topic

9

What are some facts about medical research crowdfunding?

success rate of 50-60%

small amounts $5000 - 30 000

over 30 crowd-funding research projects