Flashcards in Lecture 7 - Gram positive rods Deck (14)
Describe the gram stain appearance of Bacillus, and the disease suspected if it's found in pregnant women?
Gram positive rod, brick shaped
Which two antibiotics do you use for Listeria?
Gentomycin and amoxicillin
What is Listeria monocytogenes relationship with oxygen and temperature?
-Facultative anaerobe - prefers to grow with oxygen
- Broad range of growth temperature, can survive at 4 degrees aka in the fridge
What are the clinical syndromes of Listeria?
Bacteraemia: fever + myalgia
Slow growing meningitis
Describe Clostridium difficile's gram stain appearance, relationship with oxygen and virulence
Gram positive, regular shaped rod
Virulence is determined by production of toxins A, B and binary toxin
What disease does Clostridium difficile cause 2-30% of cases of?
Antibiotic resistant diarrhoea
What disease does Bacillus anthracis cause?
Anthrax. Clinical forms are determined by route of acquisition - cutaneous, inhalation and gastrointestinal. Both Inhalation and GI have a 100% mortality if untreated
What disease is Bacillus cereus associated with?
Food poisoning from poorly cooked, reheated rice. Endospores allow it to survive initial cooking
What does Clostridium perfringens cause?
Gas gangrene if soil spores get into the wound
Food poisoning associated with pork/chicken or turkey
Necrotizing bowel disease, from poorly cooked pork in New Guinea feast
Do Bacillus or Clostridium species produce endospores?
Where do you find lactobacillus?
In the vagina, GI tract and mouth. They are large, regular gram positive rods, most of which are facultative anaerobes
Describe the appearance of Corynebacterium
Tiny, irregular gram-positive rods "coryneform morphology"
Describe the disease caused by Coryneform diptheriae
Diphtheria, has a 30% mortality rate
Primarily infects pharynx, can cause thick white membrane which can extend down the trachea and case asphyxiation