Lecture 8: Case 3

Question 1

Identify round cell tumors 1-5

Answer 1

1. Lymphoma
2. TVT
3. MCT
4. PCT
5. Histiocytic a

Question 2

what is the most common hematopoietic tumor in animals

Answer 2

lymphoma

Question 3

lymphoma has what paraneoplastic syndrome

Answer 3

hypercalcemia

Question 4

lymphoma is characterized based on

Answer 4

1. Size
2. B, T or NK cell
3. Flow cytometry

Question 5

what is N:C ratio for lymphoma

Answer 5

high

Question 6

what are cytoplasmic features for lymphoma

Answer 6

small amount, vary hues if blue (basophilic)

Question 7

if there is not cytological confirmation of lymphoma what do you do next

Answer 7

PCR for antigen receptor rearrangement

Question 8

if there is cytological confirmation of lymphoma what do you do next

Answer 8

flow cytometry, IHC

Question 9

who does TVT occur in

Answer 9

free-roaming, sexually actives animals living in temperate climates

Question 10

how are neoplastic TVT cells transplanted

Answer 10

between MM- oral cavity, nasal cavity, genitalia

Question 11

what is N:C ratio for TVT

Answer 11

moderate

Question 12

what are some cytoplasmic features for TVT

Answer 12

distinct/punctate vacoules, pale basophilic cytoplasm

Question 13

what tumor

Answer 13

TVT

Question 14

what dogs breeds are predisposed to MCT

Answer 14

boxers, pugs, Boston terriers

Question 15

what paraneoplastic syndromes associated with MCT

Answer 15

1. Gastric ulcers
2. Localized inflammation
3. Anaphylactic shock

Question 16

what cats are predisposed to MCT

Answer 16

young Siamese and Burmese

Question 17

what is mastocytemia

Answer 17

mast cells present in circulation

Question 18

mastocytemia is always a __finding secondary to __

Answer 18

abnormal, secondary to inflammatory disease of neoplasia

Question 19

what is N:C ratio for MCT

Answer 19

moderate

Question 20

what are cytoplasmic features for MCT

Answer 20

purple granules, moderate amount of pale

Question 21

what tumor

Answer 21

MCT

Question 22

what is grade I MCT

Answer 22

well differentiated, granulated mast cells- better prognosis

Question 23

what is grade III MCT

Answer 23

high change of local reoccurrence and metastasis to regional LN

Question 24

what additional diagnostics do you do for MCT

Answer 24

1. Grade
2. FNA draining LN
3. Evaluate +/- FNA liver and spleen

Question 25

what type of tumor

Answer 25

PCT

Question 26

what is N:C ratio for plasma cells

Answer 26

moderate

Question 27

what are cytoplasmic features for plasma cells

Answer 27

perinuclear clear zone, moderate amount of deeply basophilic cytoplasm

Question 28

what are some paraneoplastic syndromes for multiple myeloma

Answer 28

1. Hypercalcemia- PTHrp or osteoblasts 2. Hyper viscosity syndrome

Question 29

need 2 of the following 4 to dx multiple myeloma

Answer 29

1. Rad evidence of osteolysis 2. >20% of plasma cells in bone marrow 3. Monoclonal gammopathy on SPE 4. Proteinuria

Question 30

canine histiocytoma more common in who

Answer 30

young dogs <3yrs

Question 31

histiocytomas originate where

Answer 31

langerhans cells in the epidermis of skin

Question 32

young dog what tumor

Answer 32

Histiocytoma

Question 33

what is N:C ratio for histiocytoma

Answer 33

moderate

Question 34

what are some cytoplasmic features for histiocytoma

Answer 34

moderate amount of pale basophilic cytoplasm

Question 35

what type of tumor

Answer 35

histiocyțoma

Question 36

plasma cell vs histiocytoma has what

Answer 36

PCT: more ansiocytosis, more ansiokaryosis, binucleation, multinucleation