Lecture 8 - Infertility Flashcards Preview

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Flashcards in Lecture 8 - Infertility Deck (21):
1

Infertility definition?

failure to conceive after 12 months of unprotected intercourse

2

Assessing male fertility?

15M/ml sperm, 40% motility, 1.5mL volume, 39mill total, 45 morphology

3

Basic assessment female fertility?

28 day period, estrogen of day 12, progeest of day 21, FSH of days 2-4, age-related graph of AMH, timing of intercourse, STIs

4

Anovulation?

result of underweight/overweight, treated with weight control or drugs: GnRH, clomiphene citrate, letrazole, FSH

5

Polycystic Ovarian Syndrome?

10% women, metabolic syndrome, infrequent or no periods, increased androgens

6

Fixing tubual disease?

surgery and IVF

7

Cervical problem treatment?

intrauterine insemination

8

Endometriosis?

10% women, treated with hormonal contraceptives and surgery (ablation)

9

Treating premature monopause, or rising FSH/decreasing AMH with age?

donor egg (IVF)

10

No uterus name and treatment?

mullerian agensis or Rokitansky syndrome, use of surrogate required

11

6 Steps of IVF?

egg production stimulated by hormone therapy, eggs retrieved by ovary, sperm sample provided, eggs and sperm combined to allow fertilisation, fertilised eggs introduced to uterus, embryo freezing

12

Drugs for ovarian control?

FSH (stimulation), GnRH antagonists (prevention), HGC and GnRH agonist (trigger ovulation), Progesterone (essential luteal support)

13

IVF cycle tracking?

ultrasound to measure follicle size, blood tests (e and p)

14

Time-lapse photography?

individual embryo tracking of cell division, uses algorithms to predict tohse with best potential without disturbing culture

15

Oligospermia?

low sperm count, can use inta-cytoplasmic sperm injection or sperm donor

16

OATS?

low, slow and abnormal sperm, treated with ICSI or donor

17

Azoospermia?

no sperm, eithe Kallmans syndrome, no spermatogenesis or congenital absence of vas d (CAVD), donor or testicular sperm aspiration (surgery)

18

Unexplained infertility problems?

unknown aetiology, fertilisation issue, age

19

Unexplained infertility treatment?

mild ovarian stimulation with intrauterine insemination, IVF

20

Aneuploidy?

eggs containing abnormal chromosome make-up, proportion increases with age

21

Looking at DNA of embryo?

preimplantation genetic screening (biopsy)