Lectures 7 & 8 Flashcards Preview

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Flashcards in Lectures 7 & 8 Deck (13):
1

Permeability

Ease by which ions pass through channel
Defined in terms of reference ion

2

A channel is selective for an ion when

It is more permeable to the ion of interest

3

All iGlus are permeant to

Monovalent cations
Na+, K+

4

Which iGlus are also permeable to divalent cation Ca2+

NMPARs
Some KARs
GluA2 lacking AMPARs

5

AMPAR conductance

Very fast
Rapid decay

6

NMDARs open

Slowly and close slowly

7

Potency is ___________ correlates with ________

Positively
Binding affinity

8

Rate of deactivation is __________ correlated with _________

Negatively
Potency

9

External Mg2+ is an

Open NMDAR channel blocker
Aka uncompetitive blocker

10

Mementine is a

Uncompetitive NMDAR blocker used to treat moderate to severe AD

11

Ketamine is a

Uncompetitive blocker of NMDAR

12

Two examples of non competitive antagonists of NMDAR

Zn2+
Ifenprodil

13

Non competitive AMPAR

Perampanel
Epilepsy treatment