Leptospirosis Flashcards Preview

Infectious Harrison's > Leptospirosis > Flashcards

Flashcards in Leptospirosis Deck (8)
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1

Typical electrolyte abnormalities in leptospirosis

Hypokalemia and Hyponatremia

2

Electrolyte abnormality uniquely associated with leptospiral nephropathy

Hypomagnesimia
(Loss of magnesium in the urine)

3

Triad of Weil’s syndrome

Hemorrhage
Jaundice
Acute kidney injury

4

Definite diagnosis of leptospirosis

1. Isolation of organism from the patient
2. Positive result in PCR
3. Seroconversion or a rise in antibody titer (fourfold or greater rise in titer detected between acute and convalescent phase serum specimens)

5

Cross reactions occur with MAT (microagglutination test) with which diseases

Syphilis
Viral hepatitis
HIV
Relapsing fever
Lyme’s disease
Legionellosis
Autoimmune disease

6

What specimens can be used for culture during the first week?

CSF and Dialysate

7

What specimen can be used from the second week of symptomatic illness?

Urine (urinary excretion may last for several weeks)

8

What is the chemoprophylaxis for Leptospirosis in adults?

Doxycycline (200 mg PO once a week)—should not be given to pregnant women or children
Azithromycin 250 mg PO once or twice a week