Leucopoiesis & Growth Factors Flashcards Preview

Basic Haemotology (1204) > Leucopoiesis & Growth Factors > Flashcards

Flashcards in Leucopoiesis & Growth Factors Deck (68):
1

Site of Leukogenesis

Bone marrow (extravascular)

2

The ratio of myeloid to erythoids in bone marrow

3:1 / 15:1

3

Life span of granulocytes

4-8 hours

4

Life span of lymphocytes

several weeks or months

5

Life span of monocytes

10-20 hours

6

How long does it take for leukocytes to mature

10-14 days

7

What leukocyte has the highest count in the body

Neutrophils

8

What leukocyte has the lowest count in the body

Basophils

9

Term given to a decreased formation of myeloid cells

Pancytopenia

10

Term given to an increase in non-functional, undifferentiated WBC

Leukemia

11

Physical characteristics of monocyte

Kidney- Shaped/ Horse- Shaped

12

Monocytes enter tissues to form....

Macrophages

13

Physical characteristics of Basophils

S- Shaped

14

Basophils move into tissue to form....

Mast Cells

15

What White Blood cell constitutes the bodies first line of defense.

Neutrophils

16

What are eosinophils used for

Parasitic infections and Allergic reactions

17

What WBC is used in muscle repairs

Neutrophils

18

What is the name of the common progenitor cell

CFU-GM

19

What 4 characteristics develop as the cells reach maturity

Chemotaxis (membrane receptors)
Phagocytosis (Contractile protein tubulin)
Lysis (lysosomal enzymes)

20

What is the exception for when surface antigens also called Human leukocyte associated antigens are identical

In identical twins

21

What causes physiologic leucopoiesis to occur ?

After exercise and adrenaline injection

22

What Growth Factors facilitate the production of macrophages

M-CSF, GM-CSF, IL-3

23

What growth factor facilitates the production of Neutrophils, Eosinophils and Basophils from Macrophages and Fibroblasts

G-CSF

24

What Growth factors facilitate the production of Neutrophils and Macrophages from T-Cells and Epidermal Cells

IL-3

25

What is the Maturation Sequence for Leucopoiesis

Myeloblast
Promyelocyte
Basophilic/ Neutrophilic/ Eosinophilic Myelocyte,
Basophilic/ Neutrophilic/ Eosinophilic Metamyelocyte
Basophilic/ Neutrophilic/ Eosinophilic band
Basophilic/ Neutrophilic/ Eosinophilic segmented

26

How many WBCs are usually formed

5,000-10,000

27

True or False WBCs, spend only a few hours in the blood stream before migrating to connective tissue

True

28

True or False, WBCs retain their organelles for protein synthesis

True

29

True or False, All WBCs have lysosomes called nonspecific (azurophillic) granules that are conspicuous, therefore very evident in cytoplasm

False, the cytoplasm is clear

30

What is the life span for granulocytes in tissues where they are needed

4-5 days

31

What are the pluripotent Stem Cells for WBCs

Myeblasts, Monoblasts, Lymphoblasts

32

What part of the body stores and releases granulocytes and monocytes

Red bone marrow

33

Granulocytes leave the bloodstream in _______ hours and live for _____ days longer

8 hours, 5 days

34

Monocytes leave the bloodstream in _______ hours and transform into _____ and live for _______

20 hours, Macrophages, several years

35

True or False, Lymphocytes as continuously recycled from blood to tissue fluid to lump and back to blood

True

36

What disease causes a decrease formation of all myeloid cell lines

Aplastic Anaemia (Pancytopenia)

37

What causes factors causes Pancytopenia

Drugs, high radiation, abnormal immune response, idiopathic

38

What disease occurs when there is an increased number of functional, nondifferented white blood cells

Leukemia

39

What are the 3 types of Myeloid stem cells

Granulocytes, Thrombocytes, Monocytes

40

What is the name of the Lymphoid Stem Cells

Lymphocytes

41

True or False, the GM-CSF stimulates cytotoxic and phagocyte activity against bacteria and parasites

True

42

What growth factors are produced by fibroblasts, strongly Cells, T-Lymphocytes and endothelial Cells

GM-CSF

43

What cells are stimulated by GM-CSF

Granulocytes, Monocytes and Erythrocytes

44

What Growth factor stimulate the proliferation and maturation of granulocyte precursors

G-CSF

45

What Growth factors are produced by Stromal Cells, Monocytes, Macrophages and endothelial Cells

G-CSF

46

What growth hormone is secreted by stromal cells, Macrophages and fibroblasts

M-CSF

47

What growth factor is a heavily glycosylated glycoproteins

M-CSF

48

What growth factor has a low molecular weight Glycoprotein

G-CSF

49

What growth factor is a potent stimulator of macrophage function and activation

M-CSF

50

What growth factor increases the expression of MHC II antigen on Macrophages

M-CSF

51

What is the second highest leukocyte count

Lymphocytes

52

What WBC has a leukocyte count of 5.3%, 2.3%, 0.4%

Monocytes, Eosinophils, Basophils

53

What WBC has 3-5 lobes

Neutrophils

54

What WBC has the ability for chemotaxis and phagocytosis

Neutrophils

55

What WBC has a bi-lobed nucleus

Eosinophils

56

What WBC has coarse granules containing lysosomal enzymes and major basic protein

Eosinophils

57

What WBC increases parasitic in parasitic infestations and allergic conditions

Eosinophils

58

What WBC has a S shaped nucleus

Basophils

59

What WBC has granules containing histamine and heparin

Basophils

60

What WBC has membrane receptors for lgE

Basophils

61

What WBC has a round nucleus with no visible nucleoli, and gets larger with a visible nucleoli when metabolically active

Lymphocytes

62

What WBC has a powerful phagocytic action

Monocytes

63

Where are Kupffer Cells located

Liver

64

What WBC are elevated in Whooping Cough

Lymphocytes

65

What WBC is elevated in Typhoid fever , MalariaC Tuberculosis

Monocytes

66

What cells are elevated in bacterial infections

Neutrophils

67

What WBC is associated with AIDS

Too few helper T cells (lymphocytes)

68

What WBC is associated with mononucleosis

Lymphocytes