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HEMA FINALS > leukemia disorder 1 > Flashcards

leukemia disorder 1 Flashcards

1
Q

absolute leukocyte counts >11.0x109
/L

A

Leukocytosis

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2
Q

absolute leukocyte counts <3.0x109
/L

A

leukopenia

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3
Q

the segmentation of neutrophil is greater
than 2-5 lobes

A

Hypersegmented neutrophil

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4
Q

Has a normal size 4-6 lobes in the nucleus found in the
stage of recovery from infection

A

polycyte

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5
Q

Larger than normal neutrophil and has 5-10 nuclear
lobes seen in pernicious anemia, the hypersegmented
neutrophils are one of the hallmark of this condition

A

macropolycyte

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6
Q

Atypical Lymphocyte also known as

A

Virocyte
Downey type cell
Turk Irritation cell

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7
Q

Atypical Lymphocyte can be seen in

A

HIVV
herpes simplex infections
infectious mononucleosis,
viral hepatitis,
viral pneumonia

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8
Q

Atypical Lymphocyte appearance

A

sunny side up
Swiss-cheese
Tunneled appearance
Moth-eaten

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9
Q
  • myelobast that is characterized by having a nucleus with deep
    indentions often suggesting lobulation
A

Rieder cell

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10
Q

Rieder cell seen in

A

acute myeloid leukemia (AML)

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11
Q

signs of degeneration in severe infections, chemical
poisoning and leukemia

cell has holes

A

Vacuolated cell

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12
Q
  • net-like nucleus from a ruptured white cell specially a PMN
A

. Basket cell or Smudge cell

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13
Q

Basket cell or Smudge cell seen in

A

chronic lymphocytic leukemia

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14
Q

Lupus Erythematosus cell also known as

A

Hargraves

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15
Q

PMN which had engulfed the nuclear material of another PMN
or a lymphocyte

A

Lupus Erythematosus

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16
Q

Monocyte with an engulfed nucleus usually of a lymphocyte
or maybe the whole lymphocyte itself

A

Tart Cell

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17
Q
  • exhibits nucleophagocytosis
A

Tart Cell

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18
Q

lymphocyte with hair like cytoplasmic projection surrounding
the nucleus

A

Hairy cell

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19
Q

rough lymph cell with nucleus that is grooved or convulated

A

. Sezary Cell

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20
Q

. Sezary Cell seen in

A

Sezary syndrome and mycosis fungoides

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21
Q

ABNORMAL INCLUSION BODIES IN LEUKOCYTES

A

Dohle - Amato Bodies
Auer bodies/rods
Toxic granules
Russel or Fush’s Bodies
Snapper-Scheid Bodies

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22
Q

are linear or spindle-shaped red-purple inclusions in
myeloblasts and monoblasts

caused by unusual
development of lysozomes

A

Auer bodies/rods

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23
Q

dark blue to purple cytoplasmic granules in the
metamyelocyte, band or in neutrophil stage

A

. Toxic granules

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24
Q

stain blue-gray usually seen in the periphery of the cytoplasm
of neutrophils

A

Dohle - Amato Bodies

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25
Q

characteristics of bacterial infections and are frequently seen
in aplastic anemia and also in myelosclerosis

A

. Toxic granules

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26
Q
  • remnants of free ribosomes from an earlier stage of
    development
A

Dohle - Amato Bodies

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27
Q

Dohle - Amato Bodies seen in

A

bacterial infection, severe burns, exposure to
cytotoxic agents and complicated pregnancies

28
Q
  • found in the cytoplasm of multiple myeloma and plasma cells
    after therapy with amidine drugs
A

Snapper-Scheid Bodies

29
Q

gamma globulins bodies in the cytoplasm of plasma cells and
inflamed tissue

A

Russel or Fush’s Bodies

30
Q

bodies which gave a grape or berry or morula cell appearance

A

Russel or Fush’s Bodies

31
Q

Not tumor related

A

Non Neoplastic Disorders

32
Q

Tumor related

A

Neoplastic and Related Disorders

33
Q

Disorder of nucleus

A

Hyper-Segmented Neutrophil
. Huet Anomaly
Pseudo-Pelger-Huet Anomaly

34
Q

Hyper-Segmented Neutrophil
Defect of change | Associated
Condition | Others

A

Abnormal DNA synthesis - Megaloblastic Anemia - Shift to the Right

35
Q

Prize-nez
appearance

Decreased
segmentation in
neutrophil

there’s something
wrong with the
mutation in the
Lamin B.

A

Huet Anomaly
Defect of change

36
Q

CMLS – Chronic
myelogenous
leukemia

MDS –
myeloproliferative
disorder syndrome

A

Huet Anomaly
Associated Condition

37
Q

Has less dense
nuclei with
hypogranular
cytoplasm

A

Pseudo-Pelger-Huet Anomaly
Defect of change

38
Q

Bums
drug reaction
infection
MDS
CML
acute leukemia
chemotherapy

A

Pseudo-Pelger-Huet Anomaly
Associated condition

39
Q

Alder Reily Anomaly associated condition

A

hunter’s syndrome
hurler’s syndrome

40
Q

Alder Reily Anomaly defect

A

accumulation of degraded mucopolysaccharides

41
Q

large peroxidase lysosome inclusion that are deficient in enzyme for phagocytosis

A

chediak-higashi syndrome defect

42
Q

May-Hegglin Anomaly defect

A

Dohle-bodies thrombocytopenia, giant pkatelets

43
Q

disorder of cytoplasm

A

Alder-Reily Anomaly
Chediak-Higashi Syndrome
May-Hegglin Anomaly
Jordan’sAnomaly

44
Q

Functional
Disorder

A

Job’sSyndrome
LazyLeukocyte Syndrome
Chronic Granulomatous Disease
CongenitalC₃ Deficiency
Myeloperoxidase
Deficiency

45
Q

Gaucher’sDisease defect

A

deficiency of
glucocerebrosidaseenzyme

46
Q

Gaucher’s Disease type I

A

non-neuronopathic

47
Q

Gaucher’s Disease type II

A

acute neuronopathic

48
Q

Gaucher’s Disease type III

A

sub-acute neuronopathic

49
Q

Gaucher’sDisease affects

A

bone
marrow, spleen
and liver

50
Q

Niemann-Pick
Disease defect

A

deficiency of sphingomyelinase

51
Q

Schuller-Christian
Disease defect

A

macrophage with cholesterol
overload

52
Q

Schuller-Christian
Disease associated condition

A

hyperlipidemia

53
Q

Monocyte-Macrophage disorder

A

Schuller-Christian
Disease
Niemann-Pick
Disease
Gaucher’s Disease

54
Q

Lymphocytes disorders

A
  • Tay-Sachs Disease
  • Bruton Agammaglobulinemia
  • Common Variable Hypogammaglobuli- nemia
  • Nezelof’s Syndrome
  • Di George’s Syndrome
  • Swiss-Type Aggamaglobulinemia
  • Wiscott-Aldrich
    Syndrome
  • Ataxia
    Telangiectasia
55
Q

reduced Ig production in blood

A

Bruton
Agammaglobulinemia

56
Q

deficiency in hexosaminidaseA

A

Tay-Sachs Disease

57
Q

underdevelopment of the
thymus

A

Nezelof’s
Syndrome

58
Q

reduced production of Ig due to
overactivity of T8cells

A

Common Variable
Hypogammaglobuli-
nemia

59
Q

deletion of a small piece of
chromosome 22

A

Di George’s
Syndrome

60
Q

loss of both T and Bcells
function

A

Swiss-Type
Aggamaglobulinemia

61
Q

decreased T cellproduction

A

Ataxia
Telangiectasia

62
Q

failure of T-cellresponse
-only IgA and IgGare
present; IgM is absen

A

Wiscott-Aldrich
Syndrome

63
Q

both random and directed movement of the cells are defective

A

Lazy leukocyte syndrome

64
Q

random movement of phagocytes is normal but directional motility is impaired

A

Job’s syndrome

65
Q

Intracellular killing mechanism of granulocyte is defective

A

Chronic Granulomatous Disease

66
Q
A

HEMA FINALS (7 decks)

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