leukemias, lymphomas and lymphoproliferative disorders Flashcards Preview

STEP 1 > leukemias, lymphomas and lymphoproliferative disorders > Flashcards

Flashcards in leukemias, lymphomas and lymphoproliferative disorders Deck (23):
1

what is mylodysplastic syndrome?

primarily effects men and occus with median age ~65

2

what type of leukemia is offten associated with DIC

acute promyelocytic leukemia with auer rods - release of auer rods is prothrombotic

DIC has long PT and PTT

3

what is the translocation for APL?

t(15;17)

4

what is a aur rod made of?

cyrstalized myeloperoxidase

5

what leukemia is most commonly seen in older adults (5th-6th decade)

AML

6

what is the consequence of t(15;17)?

results in a disruption of retinoic acid receptor (RAR) required for myeloblast maturation

ATRA is treatment for APL because it induces maturation of neoplastic cells

7

7 yr old Down syndrome pt has leukemia. What is it?

ALL

8

3 yr old downsyndrome pt has leukemia. What is it?

Acute megakaryoblastic leukemia

9

pt has leukemic infiltration of the gums. What caused this?

acute monocytic leukemia

10

child presents with lytic bone lesions and skin rash with recurrent otitis media and a mass invovling the mastoid bone. Cells are immaure and are innefective at stimulating T-cells via antigen presentation. S100 and CD1a +. What is the diagnosis?

Langerhans cell histiocytosis

proliferative dissorder of dendritic (langerhans) cells

11

leukemia in 0-14yrs of age?

ALL

12

15-39

AML

13

40-59

AML + CML

CML has >30% blasts

14

>60

chronic lymphocytic leukemia

15

5 yr old with lymphoblasts that are CD10 positive and positive to TdT.

acute lymphoblastic leukemia/lymphoma

16

what markers are seen the the most common adult leukemia?

CD20+, CD5+, smudge cells and small mature appearing lymphocytes

chronic lymphocytic leukemia

17

what hematologic condition is associated with CLL?

autoimmune hemolytic anemia

18

pt was found to have a t(11;14), what is the likely disease?

mantle cell lymphoma

19

what causes mantal cell lymphoma?

Cyclin D1 activation

20

pt is found to have a t(8;14) translocation - what is the likely disorder?

burkett lymphoma

21

what cuases burkett lymphoma?

c-myc gain of function activation of proto-onco gene

22

pt has dry tap on marrow aspiration with massive spelomegally and no lymphadenopathy. Cells stain for tattrate-resistant acid phosphatase. What is the disorder?

Hairy Cell leukemia

adult males

mature B cell tumor

23

adult pt presents with rash, hepatosplenomegally, generalized lymphadenopathy and lytic bones lesions with hypercalcemia. what do they have?

Adult T cell leukemia lymphoma

association with HTLV-1

most common in Japan and carribiean

WITHOUT RASH THIS WOULD DESCRIBE MULTIPLE MYELOMA

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