Leukocyte Antigen and Relationship Testing ( Chapter 21 ) Flashcards Preview

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Flashcards in Leukocyte Antigen and Relationship Testing ( Chapter 21 ) Deck (16):
1

Is a specialized branch or division in immunology for human histocompatibility testing

Human Leukocyte Antigen Testing

2

The first known HLA molecule

HLA-A2

3

Is a series of closely linked genes that determine major histocompatibility factors - that is surface antiges or receptors

Human Leukocyte Antigen Region/Major histocompatibility complex

4

What part of chromosome 6 can u find Class 1 HLA molecule

telomere

5

What part of chromosome 6 can u find Class 2 HLA molecule

Centromere

6

Where can u find HLA antigen

short arm of chromosome 6

7

what are the classic DR specificities

DRB1 , DRB3 (DR52 molecule) , DRB4 (DR53 molecule) DRB5 (DR51 molecule )

8

Class 3 regions structurally and functionally diverse molecules

C2 , C4 , Bf ( the complement factors ) , 21 - hydroxylase and tumor necrosis factor , GLO

9

Is present to distinguish them as significant serologic epitopes found on multiple HLA-A and HLA-B alleles rather than independent HLA specificities.

Bw4 amd Bw6

10

In HLA Gene a capital Letter indicates ______

specific locus

11

In HLA gene the second letter indicates

Subregion

12

In HLA gene the two digital numeral defines

Serologic Group Reactivity

13

In HLA gene the allele family separated by a colon

Specific Alleles

14

An event that infrequently complicates HLA-typing interpretation and haplotype determination is _______

Crossing Over/Recombination

15

It is when HLA genes occur more frequently in the same haplotype than would be expected by chance alone

Linkage Disequilibrium

16

Is used to prevent evaporation in antisera

Mineral Oil