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Flashcards in Leukocytosis and Leukopenia Deck (19)
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1

What should you use - the percentage or absolute count of the cell types on a CBC diff?

only care about the absolute

2

What's the one line where the percentage is helpful?

% of banded neutrophils

3

What blood lab changes do you see with a systemic bacterial infection?

marked toxic change
frequent left shift
leukoerythroblastic reaction
evidence of DIC

4

What are some causes of neutrophilia?

infections
tissue damage
hemolysis (acute)
acute blood loss
collage-vascular disorders
vasculitis
colitis
nephritis
hypersensitivity rxns
uremia
DKA
eclampsia
exercise
pregnancy
stress
surgery
myeloid disorders
malignant neoplasms

5

What are some examples of drug-induced neutrophilia?

corticosteroids
lithium
growth factors

6

What lifestyle activity can cause neutrophilia?

cigarettes

7

Neutropenia is usually caused by what two things?

Bugs or drugs

8

True or false: normal range for neutrophils varies depending on age and ethnicity.

true

kids have a lower normal range, as do african americans

9

What are the most common causes of monocytosis?

Infecions - esp chronic
(Viral, bacterial, esp things with granulomas)

endocarditis
GI disorders
sarcoid
hodgkins
myeloid disorders
solid tumors
collagen-vascular disorders

10

What are the three main causes of monocytopenia?

aplastic anemia
B-cell leukemias
glucocorticoid adminstration

11

What are the most common cause of eosinophilia?

drug reactions
allergies
parasitic infections

12

What are some causes of basophilia?

asthma
urticaria
anaphylaxis
CML!!!
parasites
allergies
hypothyroidism
inflammatory process
TB
Viral infections
Mast cell disease
renal failure

(and basically any time there is an eosinophilia)

13

What are the infections that can cause mononucleosis syndromes?

EBV
CMV
HHV-6
HSV-2
VZV
HIV
Hepatitis
Adenoviruses
Toxo
Bordatella pertussis (classic appearance)

14

Mononucleosis is often characterized by a mild absolute ___ocytosis

lymphocytosis (over 4, but less than 20)

15

If lymphocyte count is over 20, what do you need to think about?

leukemia

infections will never get that high.

16

Lymphocytopenia usually implies reduction in what T cell opulation?

CD4+

17

Why don't we get as excited about lymphocytopenia as neutropenia?

people can manage to walk around with low lymphocytes without too much problem with infection until something goes awry

it's less of an emergency

18

What are some causes of lymphocytopenia?

cong immunodeficiencies
viral infections (esp HIV, HHV8)
autoimmune disorders (SLE)
Sarcoid
zinc deficiency
malignant lymphoma
Hodgkin's disease

19

What are some of the drug realted causes of lymphocytopenia?

corticosteroids
immunosuppressive agents
antineoplastic agents
radiation therapy