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GastroIntestinal (GI) > LFT > Flashcards

Flashcards in LFT Deck (28):
1

What is measured in a Liver function test?

Bilirubin
Alkaline phosphatase
Gamma Glutamyl transferase

2

What other factors are important to measure to see the health of the liver?

Albumen
Prothrombin time

3

What are symptoms of liver disease?

Weight loss
Malaise
Right upper quadrant pain
Colour of urine and stools
Jaundice

4

What are "red flags" for live disease in past medical history?

Metabolic syndrome
Alcohol dependence
Malignancy

5

What are signs of liver disease on examination?

Jaundice
Clubbing
Palmar erythema
Xanthelasmata
Spider Naevi
Abdominal masses
Hepatomegaly

6

When is jaundice clinically apparent?

Bilirubin over 35

7

What is Gilbert's syndrome?

Isolated Mild Hyperbilirubinaemia

8

What is the cause of increased bilirubin production?

Haemolysis
Ineffective erythropoiesis
Haematoma resoprtion

9

What are the causes of reduced hepatic uptake?

Gilbert's syndrome

10

What are the reasons for a raised ALP ( alkaline phosphatase)

Bile duct obstruction
Primary sclerosing cholangitis
Primary Biliary cirrhosis
Malignancy

11

With respect to liver function tests what is found in bone marrow as well as liver?

ALP (Alkaline phosphatase)

12

What does a LFT measure?

Bilirubin, albumin and prothrombin time - true LFT
Test liver function test

13

What a liver damage tests?

Alkaline phosphatase
Alanine amino transferase
Gamma Glutamyl transferase (GGT)

14

What are cholestatic Liver function tests?

Alkaline phosphataase
GGT

These are enzymes that are damaged during biliary obstruction.

15

What are hepatitis/Hepatocellular LFT?

Alanine amino transferase (ALT)

16

What are true liver function tests?

Bilirubin
Albumin
Prothrombin time

17

What are the liver screening tests?

FBC
Urea electrolytes
Clotting
LFT
Liver immunology
Serum selenium
HBV
Alpha 1 antitrypsin
Ferritin
Caeuroluplasmin (low in wilsons)

18

What are the signs of cholestatic jaundice?

Post - hepatic jaundice
Raised ALP
Raised GGT
Pale stools, dark urine

19

What are the signs of gall stones?

Somatic pain
Jaundice

20

What are the painless causes of jaundice?

Pancreaticarinoma
Primary biliary cirrhosis - however would have a history
Cholangiocarcinoma

21

What is the single investigation you would do for jaundice?

Ultra sound.
This will be able to tell if the bile duct is dilated/not dilated.

22

After using an ultra sound and you find a dilated bile duct what should you do?

CT scan first
then ERCP - endoscopic retrograde cholangiopancreatography (allows you to remove the gall stone and bypass the lesion)

23

What would you do after an ultra sound if you find a non-dilated bile duct?

Monitor LFT
Liver biopsy

24

What does a non - dilated bile duct suggest?

Intrahepatic jaundice
Drug induced

25

What does dilated bile duct suggest?

Obstruction
Gall stones
Cancer

26

What investigation would you do for suspected hepatitis?

MRI liver

27

How would you diagnose autoimmune hepatitis?

Monitor LFT
Liver biopsy

28

What does a raised AST mean?

There is a problem, somewhere but doesn't specifically mean liver.