Flashcards in LG3.9 Pathology of Joint Disorders – Dr. Fischione Deck (20):
What is the most common joint disease?
Who is most likely to get Osteoarthritis?
Where joints are most likely to be affected by Osteoarthritis?
Weight bearing joints
What is pathology of Osteoarthritis?
-Eburnation-sclerosis of the subchondral plate
-Fibrillation of articular cartilage forms vertical clefts
-bone cysts and osteophytes form
What is the spine involvement in osteoarthritis?
Usually affects cervical or lumbar area, DJD involves primarily the inter-vetebral joint.
What and where are Herberden's Nodules?
Nodular deformities of the DIP joints
What and where are Bouchard's Nodules?
Nodular deformities of the PIP joints
How are the Feet involved in OA?
(1st MCP, bunions) Shows deformities of the toes, the most common is joint disease involving the 1st metatarsophalangeal joint which leads to the formation of bunions.
What are the main characteristics of Rheumatoid Arthritis?
Chronic AI usually symmetric in MCP, PIP, wrist
What is the pathology of Rheumatoid Arthritis?
Synovitis-->inflammatory cell recruitment-->Pannus
What is Pannus?
The exuberant synovial fronds transform into granulation tissue.
What is ankylosis?
Collagenous scar due to joint immobilization
What are the characteristics/symptoms of RA?
Insidious onset, sterile inflammation, systemic disease, low grade fever, loss of appetite malaise
What are the characteristics of wrist RA?
Ulnar deviation, Z deformity, swan neck, hourglass deformities.
What are rheumatoid nodules?
Subcutaneous noodles that are seen in many anatomic sites besides the joints, composed of central fibrinoid necrosis surrounded by macrophages and lymphocytes.
What is Pigmented villonodular synovitis?
-Benign tumor of the synovial lining.
Characteristics of Pigment villonodular synovitis?
-Usually monoariticular in young adults.
-Most common in knee
-Mononuclear cells, pigmented heosidein, later macrophages.
-Develops enlarged folds and nodular excrescences
What is Nodular tenosynovitis?
-Also known as Giant Cell tumor of the Tendon sheath
-Variant of PVS
What is the most common soft tissue tumor of the hands?