LG4.15 Molecular Biology of Cancer – Dr. Olson Flashcards Preview

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Flashcards in LG4.15 Molecular Biology of Cancer – Dr. Olson Deck (11):
1

I see a patient that has cystic fibrosis, but his symptoms are mild, with limited lung involvement, and does not currently need medication. This is a good example of:
a) Penetrance
b) Expressivity
c) Allelic heterogeneity
d) Locus heterogeneity

Expressivity

2

I am sequencing a cDNA library that I subcloned from a subject with schizophrenia. When comparing it to the HUGO database, I see that there are 4 polymorphisms spread across 2 separate chromosomes that are candidates for primary disease causation. This might be:
A) Penetrance
B) Expressivity
C) Allelic heterogeneity
D) Locus heterogeneity

D) Locus heterogeneity

3

I have a patient for schizophrenia, and both parents exhibit symptoms. He has three siblings that show signs, but a fourth sibling does not show it. What could be going on here?
A) Expressivity
B) Penetrance
C) Allelic heterogeneity
B) Locus heterogeneity

A) Expressivity
B) Penetrance

4

What are the two cycle checks?

1) G1 to S
2) G2 to M

5

What class of cancer causing gene do you think retinoblastoma would fall under?
a) Oncogene
b) Tumor suppressor gene

Tumor suppressor gene

6

I have a proto-oncogene that is regulating the cell cycle. A mutation in that gene creates a growth hormone receptor that is constitutively “on.” This mutation is a:
a) Loss of function mutation
b) Gain of function mutation
c) Dominant negative mutation

b) Gain of function mutation

7

I have a tumor suppressor gene that needs a “two-hit” to take out. The mutation that I am creating if I need to hit both alleles to affect the phenotype is a:
a) Loss of function mutation
b) Gain of function mutation
c) Dominant negative mutation

a) Loss of function mutation

8

If a oncogene can create an oncogenic state by mutating one copy of a proto-oncogene, the oncogene is probably going to be a ____ mutation to the proto-oncogene.
1) Dominant
2) Recessive
3) Co-dominant
4) Partial dominant

Dominant

9

A tumor suppressor that needs a “two-hit” would classify the mutated allele as being a ____ mutation.

1) Dominant
2) Recessive
3) Co-dominant
4) Partial dominant

B) Recessive

10

What is Senescence?

– irreversible state of dormancy

11

What is the best cancer therapy?

Assassinate: immune system boosters