Limbic system - Hippocampus - amyg Flashcards Preview

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Flashcards in Limbic system - Hippocampus - amyg Deck (11):
1

Declarative memory
- lesions where causes impairment in dec. mem?

ability to recollect events or facts that have a specfic temporal and spatial context.

- Hippocampus

2

Procedural memory

ability to learn new motor skills

3

what kind of memory is affectd by lesions in frontal cortex?

short term memory

Working memory
- lasts sec-min

4

_____ is the site for long term memory storage.

Hippocampus is important in formation and consolidation of _______ memory

neocortex

long term declarative
- which is stored in neocortex

5

pt HM has had medial temporal lobe resection. He has problems in ______ memory, but not _____ memory

declarative memory,
procedural memory (a-ok)

(aka had his hippocampus removed)

6

____ is imp in form of declarative memory.
_____ is imp in formation of procedural memory

hippocampus

Cerebellum/striatum/frontal cortex
- proc. mem: ability to learn new motor skills

7

How do hippocampal synapses undergo LTP?

Trisynaptic circuit

Entorhinal cortex → (perforant path) → dentate gyrus → (mossy fibers) → CA3→ (Shaeffer cells) → CA1 → (feedbacks/autoassociation on C3) → entorhinal cortex

(Both CA1 and CA3 can undergo LTP)
- repeated stim. of CA3 or CA1 neurons lead to LTP
(both loc on Hippocampus)

Failure to maintain LTP in the hippocampus can be due to AB protein deposition

8

Kluver Bucy syndrome

removal of amygdala -
important in expression of emotion.

9

Conditioned flavor aversion (CFA)

eat food → widespread ACh spread throughout brain → insular cortex (taste response) → (NMDA P) → Amygdala

(if antagonists are perfused to insular cortex = no food aversion)

10

(select ips/contralateral)
Projections from the Cerebellum are _____, but it affects ________

contralateral,
presents as ips

11

Papez (memory) circuit vs Amygdala (emotion) circuit

Papez:
hippocampus → fornix →mamillary bodies → ant. nucleus of thalamus → cingulate gyrus (cortex)

Amygdala:
amgydala → stria terminalis → steptal area or hypothalamus → amygdala