Limbic system - Hippocampus - amyg Flashcards Preview

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Flashcards in Limbic system - Hippocampus - amyg Deck (11)
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1
Q

Declarative memory

- lesions where causes impairment in dec. mem?

A

ability to recollect events or facts that have a specfic temporal and spatial context.

  • Hippocampus
2
Q

Procedural memory

A

ability to learn new motor skills

3
Q

what kind of memory is affectd by lesions in frontal cortex?

A

short term memory

Working memory
- lasts sec-min

4
Q

_____ is the site for long term memory storage.

Hippocampus is important in formation and consolidation of _______ memory

A

neocortex

long term declarative
- which is stored in neocortex

5
Q

pt HM has had medial temporal lobe resection. He has problems in ______ memory, but not _____ memory

A
declarative memory,
procedural memory (a-ok)

(aka had his hippocampus removed)

6
Q

____ is imp in form of declarative memory.

_____ is imp in formation of procedural memory

A

hippocampus

Cerebellum/striatum/frontal cortex
- proc. mem: ability to learn new motor skills

7
Q

How do hippocampal synapses undergo LTP?

A

Trisynaptic circuit

Entorhinal cortex → (perforant path) → dentate gyrus → (mossy fibers) → CA3→ (Shaeffer cells) → CA1 → (feedbacks/autoassociation on C3) → entorhinal cortex

(Both CA1 and CA3 can undergo LTP)
- repeated stim. of CA3 or CA1 neurons lead to LTP
(both loc on Hippocampus)

Failure to maintain LTP in the hippocampus can be due to AB protein deposition

8
Q

Kluver Bucy syndrome

A

removal of amygdala -

important in expression of emotion.

9
Q

Conditioned flavor aversion (CFA)

A

eat food → widespread ACh spread throughout brain → insular cortex (taste response) → (NMDA P) → Amygdala

(if antagonists are perfused to insular cortex = no food aversion)

10
Q

(select ips/contralateral)

Projections from the Cerebellum are _____, but it affects ________

A

contralateral,

presents as ips

11
Q

Papez (memory) circuit vs Amygdala (emotion) circuit

A

Papez:
hippocampus → fornix →mamillary bodies → ant. nucleus of thalamus → cingulate gyrus (cortex)

Amygdala:
amgydala → stria terminalis → steptal area or hypothalamus → amygdala