Lipid Synthesis Flashcards Preview

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Flashcards in Lipid Synthesis Deck (14):
0

The fatty acid synthase complex resides in the _____, and therefore it utilize ______ acetyl-coA

Cytosol
Cystoslic

1

Acety-coA cannot pass trough __________ but citrate can.

mitochondria inner membrane

2

The reciprocal regulation of ________ and _______ occurs trough changes in the intramitochondrial acetyl-coA concentration

Pyruvate carboxylase
Pyruvate dehydrogenase

3

______ generates cytoslic acetyl-coA plus oxaloacetate

Citrate lyase

4

The high insulin/glucagon ratio after a carbohydrate meal induces the synthesis of _____(3 enzymes)

Malic enzyme
Glucose-6-phosphate dehydrogenase
Citrate lyase

5

______ is the rate limiting step of fatty acid synthesis

Acetyl-coA carboxylase

6

_______ allosterically activates acetyl-coA carboxylase while ____ inhibits it

Citrate
Palmitoyl-coA

7

In fasting state, _____ inhibits acetyl-coA through _________

Amp
Phosphorylation

8

In fed state, increased ________ induces both acetyl-coA carboxylase and fatty acid synthase

Insulin/glucagon ratio

9

Acetyl-Coa carboxylase converts ______ to ______

Acety-coA
Malonyl-coA

10

Resynthesis of dietary triglyceride occurs in the ____

Intestine

11

Fatty acid elongation occurs in the _____

Endoplasmic reticulum

12

Elongation of fatty acid is similar to fatty acid synthesis except that fatty acyl chain is attached to ____ rather than phosphopanteteheinyl residue of ACP

CoA

13

Desaturation of fatty acid occurs in the ___ and involve the oxidation of ___ and _____

ER
O2 NADH