Flashcards in Lipids 3 Deck (26):
Where do we get FA's?
Where does FA synthesis occur in the body?
- Lactating mammary
- Adipose tissue
Where does synthesis occur in the cell?
What are FA's synthesised from?
Where is the acetyl CoA from in FA synthesis?
When does the citrate cycle occur? (when what is in high concentration)?
What 2 enzymes are required for FA synthesis?
- Acetyl CoA carboxylase
- FA synthase
What are the 2 required molecules for synthesis?
- Acetyl CoA
What is the product of FA synthesis?
What is acetyl CoA initially converted to?
What other action does Malonyl CoA have to stop synthesis and degradation occurring simultaneously?
Inhibits carnitine palmitoyl transferase
What activates acetyl CoA carboxylase?
What deactivates acetyl CoA carboxylase?
- Palmitoyl CoA
What does malonyl CoA combine with in the elongation reaction
What happens after elongation?
The reverse of FA degradation
What is used in the reverse of degradation instead of NADH?
How many times is the elongation reaction carried out?
What is produced initially by the elongation reaction?
How is palmitoyl CoA produced?
Cleaved from palmitoyl ACP
What 2 pathways does the NADPH required for synthesis come from?
- Pentose phosphate pathway
- Production of pyruvate from malate in the CAC
What happens to the FA after it has been synthesised?
Transported to the liver
What happens to the FA in the liver and how is it transported to the adipose tissue?
- Synthesised into TAG
- Transported through VLDL
What is the starting lipid for the production of steroid hormones?
What are eicosanoids produced from?
- FA's longer than 20 C's
- Omega 3/6 from linolenic acid
What are 4 examples of eicosanoids?
- Arachidonic acid