Lipids 3 Flashcards Preview

Science for Med Revision > Lipids 3 > Flashcards

Flashcards in Lipids 3 Deck (26):
1

Where do we get FA's?

- Diet
- Synthesis

2

Where does FA synthesis occur in the body?

- Liver
- Lactating mammary
- Adipose tissue

3

Where does synthesis occur in the cell?

Cytosol

4

What are FA's synthesised from?

Acetyl CoA

5

Where is the acetyl CoA from in FA synthesis?

Mitochondria

6

When does the citrate cycle occur? (when what is in high concentration)?

Citrate

7

What 2 enzymes are required for FA synthesis?

- Acetyl CoA carboxylase
- FA synthase

8

What are the 2 required molecules for synthesis?

- Acetyl CoA
- NADPH

9

What is the product of FA synthesis?

Palmitic Acid

10

What is acetyl CoA initially converted to?

Malonyl CoA

11

What other action does Malonyl CoA have to stop synthesis and degradation occurring simultaneously?

Inhibits carnitine palmitoyl transferase

12

What activates acetyl CoA carboxylase?

- Citrate
- Insulin

13

What deactivates acetyl CoA carboxylase?

- Palmitoyl CoA
- Glucagon
- Epinephrine

14

What does malonyl CoA combine with in the elongation reaction

Acetyl ACP

15

What happens after elongation?

The reverse of FA degradation

16

What is used in the reverse of degradation instead of NADH?

NADPH

17

How many times is the elongation reaction carried out?

6 times

18

What is produced initially by the elongation reaction?

Palmitoyl ACP

19

How is palmitoyl CoA produced?

Cleaved from palmitoyl ACP

20

What 2 pathways does the NADPH required for synthesis come from?

- Pentose phosphate pathway
- Production of pyruvate from malate in the CAC

21

What happens to the FA after it has been synthesised?

Transported to the liver

22

What happens to the FA in the liver and how is it transported to the adipose tissue?

- Synthesised into TAG
- Transported through VLDL

23

What is the starting lipid for the production of steroid hormones?

Cholesterol

24

What are eicosanoids produced from?

- FA's longer than 20 C's
- Omega 3/6 from linolenic acid

25

What are 4 examples of eicosanoids?

- Leukotrienes
- Prostaglandins
- Arachidonic acid
- Thromboxanes

26

What enzymes synthesise prostaglandins?

- COX enzymes