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Flashcards in Liver Deck (11):
1

Aetiology

o Associated with chronic viral hepatitis B
o Ageing population
o Obesity
o Males
o Poor diet
o Alcohol

Indigenous Australians
♣ 3x more likely to die from
♣ 2.1x as likely to be hospitalised from compared to Australian pop
♣ Lower chance of survival 1 year following diagnosis ( 21% v 33%)

2

Signs and symptoms

o Abdominal pain, weight loss

o If hepatic mass is present: hepatic failure, ascites and other signs of chronic liver disease, alpha-fetoprotein (afp) is elevated in 50-70% of patients

3

Hepatic tumours are classified as ___, ____ and ______. They invade ____.

o Unifocal
o Infiltrating
o Multifocal (50%)
o Portal veins

4

T1 Staging

Solitary tumour without vascular invasion

5

T2 Staging

Solitary tumour with vascular invasion

6

T3 Staging

a: multiple tumours more that 5cm

b: single tumour or multiple tumours of any size involving a major branch of the port or hepatic vein

7

T4 Staging

tumour(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum

8

What chemo drug is used?

Doxorubicin - response rate 10-20%

9

What is the only hope of long term survival?

surgery - only possible in 20% of cases
Hepactectomy or transplantation

10

Why isn't RT generally used?

dose limiting factors of liver - radiation hepatitis

11

Common form of cancer?

Hepatocellular Carcinoma