Flashcards in Liver Deck (11):
o Associated with chronic viral hepatitis B
o Ageing population
o Poor diet
♣ 3x more likely to die from
♣ 2.1x as likely to be hospitalised from compared to Australian pop
♣ Lower chance of survival 1 year following diagnosis ( 21% v 33%)
Signs and symptoms
o Abdominal pain, weight loss
o If hepatic mass is present: hepatic failure, ascites and other signs of chronic liver disease, alpha-fetoprotein (afp) is elevated in 50-70% of patients
Hepatic tumours are classified as ___, ____ and ______. They invade ____.
o Multifocal (50%)
o Portal veins
Solitary tumour without vascular invasion
Solitary tumour with vascular invasion
a: multiple tumours more that 5cm
b: single tumour or multiple tumours of any size involving a major branch of the port or hepatic vein
tumour(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum
What chemo drug is used?
Doxorubicin - response rate 10-20%
What is the only hope of long term survival?
surgery - only possible in 20% of cases
Hepactectomy or transplantation
Why isn't RT generally used?
dose limiting factors of liver - radiation hepatitis