Flashcards in Liver Disease Deck (32):
What does Cirrhosis of the liver cause?
Reduced Metabolic Capacity
High Portal Pressure
Shunting of blood
What are the three major symtpoms of liver failure?
Reduced blood flow to liver
Reduced Metabolic function
Reduced Plasma Proteins
What drugs are used to treat for ascites and liver failure?
Non-steroidal Anti-inflammatory (NSAID)
What is the caput medusa?
Engorged periumbilical veins.
Sign of liver disease
When taking a drug explain how the order of the reaction changes as saturation increases?
Metabolism starts off as first order - you metabolise at a constant rate (straight line)
Metabolise them becomes a zero order reaction.
In liver disease explain the plasma changes?
There is a low albumen therefore a low plasma volume
What secondary disease forms in
What effect does liver disease have on hormones?
Increased Endothelin (VASOCONTRSCTOR)
What side effect is associated with endothelin?
What effect does liver disease have on the kidney?
What does the increased amounts of endothelin cause on the kidney?
What is the treatment for liver disease?
What is the side effect of NSAID?
What in alcoholic's brain causes respiratory depression?
What effect does sedative opiates have on the body?
Brings about respiratory depression.
Describe the two mechanisms how drugs can be metabolised?
Phase I - Biotransformation (Fat soluble drugs)
Phase 2 - Conjugation (Glycoronidation)
For liver diseased patients what type of drugs should you try and choose?
Phase 2 Conjugation drugs
Describe how Paracetamol is metabolised?
Paracetamol is metabolised. This produces a highly reactive by product of N-acetyl-P-benzyoquinonimine
This is removed by Glutathione
What occurs in paracetamol toxicity?
N-acetly-p-benzoqinonimine levels build up.
Glutathione stores remove as much as they ca, however is all used up.
This causes N ace levels to cause damage to the liver.
What can induce hepatitis?
Anti-biotics ( Amoxicillin/ Flucloicillin)
What is the best diuretic for liver disease?
What drugs are used for sedation in liver disease?
Phase 2 metabolised benzodiazepines
What are the worst hepatic disorders?
Fulminant Hepatic Failure
Severe acute or chronic hepatitis
Severe Congestive Heart Failure
What is the main message for when administering drugs to a liver disease patient?
What is Odynophagia?
Pain while swallowing
What is Haematemesis?
Blood in vomit
What is dyspepsia?
Patient comments of difficulty digesting
What is a side effect of jaundice?
If there is abdominal pain and jaundice what is a likely causes of the jaundice?
If there is no abdominal pain however jaundice what is the likely causes of the jaundice?
What is cirrhosis of the liver?
The liver is replaced by scar tissue. This gets worsened worse.