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Flashcards in Liver Disease Deck (17):
1

What is of the definition acute liver disease?

Rapid development of hepatic dysfunction

2

What actually is acute liver disease?

Any insult to the liver causing damage in a previously healthy and normal liver

3

What is acute liver failure?

Damage that causes encephalopathy and prolonged coagulation

4

How does acute liver disease present?

Jaundice
Lethargy
Nausea
Anorexia
Pain
Itching
Arthralgia
ABNORMAL LFTs

5

What can cause Acute liver disease?

Viral hepatitis
Eppstein Barr Virus
Drugs
Shock liver (ischaemic hepatitis)
Cholangitis
Alcohol
Malignancy
Paracetemol

6

What are the more rarer causes of acute liver disease?

Budd Chiari
Acute fatty liver of pregnancy
Cholestasis of pregnancy

7

How do you diagnose acute liver disease?

LFT's
Prothrombin time
History and exam
Ultra sound
Virology
Investigations of chronic liver disease
Liver biopsy (rarely)

8

What is the treatment for acute liver disease?

Rest, 3-6months for recovery
Fluids
NO alcohol
Increase calories, reduce fat
Treat itch with bicarbonate bath/cholestryamine/uresodeoxycholic acid
Observe for fulminant liver failure

9

What are the nutritional requirements for acute liver disease?

Increase protein and calorie intake
Consider how low their appetite may be and take steps to conquer that
May require NG feeding
Supplement K, PO4 adn Mg

10

Which drugs can cause acute liver disease?

Antibiotics like coamoxiclav, flucloxacillin
NSAIDs
Statins (rare)
Drugs like "fat burners" and "protein powders"
Paracetemol

11

What is fulminant hepatic failure?

Jaundice and encephalopathy in those patients with a previously normal liver

12

What can commonly cause FHF?

Paracetemol
Viral causes
Drugs
Hep B

13

What can rarely cause FHF?

AFLP
Mushrooms
Malignancy
Wilsons
Budd Chiari
Hep A

14

What is Budd Chiari?

Occlusion of the hepatic vein

15

What are the complications of FHF?

Encephalopathy
Hypoglycaemia
Coagulopathy
Circulatory failure
Renal failure
Infection

16

What is the treatment for FHF?

Support
Fluids
Inotropes
Renal replacement
Transplant

17

Which drug in the treatment of rheumatoid arthritis can cause liver disease?

Methotrexate