Liver Disease Pathology

Question 1

what are the indications for liver biopsy

Answer 1

acute and chronic liver dysfunction; hepatomegaly; space occupying lesion

Question 2

what are the options for liver biopsy

Answer 2

open, laparoscopic, transjugular, fine needle aspiration cytology, per cutaneous

Question 3

what are the results of acute injury

Answer 3

death or resolution with complete recovery

Question 4

how does acute injury resolve with complete recovery

Answer 4

regeneration of parenchyma, and no fibrosis

Question 5

what are the results of chronic injury

Answer 5

distortion due to fibrosis, nodules, cirrhosis

Question 6

what causes acute hepatitis

Answer 6

hep viruses; EB, CMV, yellow fever; leptospirosis

Question 7

what causes chronic hepatitis

Answer 7

HBV, HCV, Q fever, brucellosis, TB

Question 8

what are the autoantibodies present in type 1 autoimmune hep

Answer 8

ASM, ANA, AAA, ASLA/LP

Question 9

what are the autoantibodies present in type 2 autoimmune hep

Answer 9

ALKM1, ACL-1

Question 10

what happens in alcoholic liver disease

Answer 10

steatosis, steatoheptatitis, perivenular fibrosis, micronodular cirrhosis

Question 11

what are some features of steatohepatitis

Answer 11

spotty (focal) liver cell necrosis, neutrophils, Mallorys hyaline