Flashcards in Local Anesthetics Deck (15)
What are the two classes of local anesthetics?
amide and ester type
What is the approximate pK of LA?
Are LAs more ionized or less ionized at physiologic pH?
Where do LA work?
intracellular side of VG Na+ channels
How do LA get across the cell membrane?
non-ionized form crosses
non-ionized form is ionized
ionized form is active on VG Na+ channels
What is the active form of LA?
What form of LA crosses the membrane?
LA work on NA channels at what stages:
only open and inactivated
more potent on more active neurons
Side effect of LA with regards to circulation?
sm. muscle VG Na+ channels also blocked
==>faster clearing of drug
Why is epinephrine added to more LA preparations?
they cause vasoconstriction
Where are ester LA metabolized?
Where are amide LA metabolized?
What type of LA is more common to produce a hypersensitivity reaction?
What is a Bier block?
IV admin of LA with tourniquet