Local Anesthetics Flashcards Preview

Clinical Pharm > Local Anesthetics > Flashcards

Flashcards in Local Anesthetics Deck (67):
1

Esters

One "i"

2

Amides

Two "i"

3

Procaine class

Ester

4

Procaine pKa

8.9

5

Procaine relative potency

1

6

Procaine onset

2-5 min

7

Procaine duration

25-60 min

8

Procaine max dose

7 mg/kg

9

Procaine max dose with epi

10 mg/kg

10

Procaine max total dose

350-600 mg

11

Procaine concentrations with clinical use

Spinal 10%

12

Chloroprocaine class

Ester

13

Chloroprocaine pKa

8.7

14

Chloroprocaine relative potency

8

15

Chloroprocaine onset

5-10 min

16

Chloroprocaine duration

15-30 min

17

Chloroprocaine max dose

11 mg/kg

18

Chloroprocaine max dose with epi

14 mg/kg

19

Chloroprocaine max total dose

800 mg

20

Chloroprocaine concentrations with clinical use

epidural 2-3%

21

Bupivacaine class

Amide

22

Bupivacaine pKa

8.1

23

Bupivacaine relative potency

8

24

Bupivacaine onset

5-10 minutes

25

Bupivacaine duration

2-4 hours

26

Bupivacaine duration with epi

3-7 hours

27

Bupivacaine max dose

2.5 mg/kg

28

Bupivacaine max dose with epi

3 mg/kg

29

Bupivacaine max total dose

175 mg

30

Bupivacaine max total dose with epi

225 mg

31

Bupivacaine concentrations with clinical uses

epidural/spinal 0.5-0.75%
Peripheral nerve block 0.25-0.5%

32

Ropivacaine class

Amide

33

Ropivacaine pKa

8.1

34

Ropivacaine relative potency

6

35

Ropivacaine onset

10-15 minutes

36

Ropivacaine duration

2-6 hours

37

Ropivacaine max dose

5 mg/kg

38

Ropivacaine max total dose

200 mg

39

Ropivacaine concentrations with clinical use

Epidural, spinal, peripheral nerve block 0.5-1%

40

Lidocaine class

Amide

41

Lidocaine pKa

7.9

42

Lidocaine relative potency

2

43

Lidocaine onset

44

Lidocaine duration

30 min - 2 hours

45

Lidocaine duration with epi

2-6 hours

46

Lidocaine max dose

4.5 mg/kg

47

Lidocaine max dose with epi

7 mg/kg

48

Lidocaine max total dose

300 mg

49

Lidocaine concentrations with clinical use

Bier block 0.25-0.5%
Peripheral nerve block 1-1.5%

50

Prilocaine class

Amide

51

Prilocaine pKa

7.9

52

Prilocaine relative potency

2

53

Prilocaine onset

54

Prilocaine duration

60-90 minutes

55

Prilocaine max dose

6 mg/kg

56

Prilocaine max dose with epi

9 mg/kg

57

Prilocaine max total dose

70 Kg - 600 mg

58

Prilocaine concentration with clinical use

Epidural 2-3%
Peripheral nerve block 0.5-1%

59

Mepivacaine class

Amide

60

Mepivacaine pKa

7.6

61

Mepivacaine relative potency

2

62

Mepivacaine onset

3-5 minutes

63

Mepivacaine duration

60-90 minutes

64

Mepivacaine duration with epi

2-6 hours

65

Mepivacaine max dose

7 mg/kg

66

Mepivacaine max total dose

400 mg

67

Mepivacaine concentration with clinical use

0.5-1%