Flashcards in Long non-coding RNAs Deck (27):
Define a long non-coding RNAs.
Non-protein coding RNA with transcripts longer than 200nt.
What are some examples of lncRNAs?
How much of the genome are lncRNAs?
How many lncRNAs in humans?
How can 35,000 lncs be transcribed from 10,000 loci?
- Multiple splice sites.
What are some properties of lncRNAs?
How many lncRNAs in other organisms?
How abundant are lncRNAs within a cell and where are they localised?
Where are lncRNAs genomically placed?
Are lncRNAs conserved or not?
Non-conservation of lncRNAs indicate?
What is the function of lncRNAs?
What are the possible mechanisms in the nucleus and cytoplasm?
What is the structure of the PRC2 complex?
What is the function of the PRC2 complex?
Give an example of lncRNAs are a scaffold molecule.
- P54nrb + NoNo.
Give an example of phenotype loss of lncRNAs.
What are some examples of the biological roles of lncRNAs?
What does the low sequence conservation of lncRNAs imply?
How would lncRNAs arise from gain of function? Give evidence.
Can lncRNAs be post-transcriptionally modified? If so give examples.
How were lncRNAs discovered in Arabidopsis?
What is the distribution of transcribed lncRNAs in the genome?
What does specific enrichments correspond to?
Look at this bit in the elcture, page 5.
How can you determine the function of lncRNAs?