Long non-coding RNAs Flashcards Preview

Developmental Genetics > Long non-coding RNAs > Flashcards

Flashcards in Long non-coding RNAs Deck (27):
1

Define a long non-coding RNAs.

Non-protein coding RNA with transcripts longer than 200nt.

2

What are some examples of lncRNAs?

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3

How much of the genome are lncRNAs?

5-10%

4

How many lncRNAs in humans?

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5

How can 35,000 lncs be transcribed from 10,000 loci?

- Multiple splice sites.

6

What are some properties of lncRNAs?

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7

How many lncRNAs in other organisms?

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8

How abundant are lncRNAs within a cell and where are they localised?

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9

Where are lncRNAs genomically placed?

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10

Are lncRNAs conserved or not?

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11

Non-conservation of lncRNAs indicate?

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12

What is the function of lncRNAs?

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13

What are the possible mechanisms in the nucleus and cytoplasm?

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14

What is the structure of the PRC2 complex?

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15

What is the function of the PRC2 complex?

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16

Give an example of lncRNAs are a scaffold molecule.

- Neat1
- P54nrb + NoNo.
- Paraspeckles.

17

Give an example of phenotype loss of lncRNAs.

Crano

18

What are some examples of the biological roles of lncRNAs?

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19

What does the low sequence conservation of lncRNAs imply?

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20

How would lncRNAs arise from gain of function? Give evidence.

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21

Can lncRNAs be post-transcriptionally modified? If so give examples.

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22

How were lncRNAs discovered in Arabidopsis?

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23

What is the distribution of transcribed lncRNAs in the genome?

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24

What does specific enrichments correspond to?

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25

Look at this bit in the elcture, page 5.

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26

How can you determine the function of lncRNAs?

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27

Can transposons promote lncRNA transcription?

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