Flashcards in Loop of Henle, Distal Tubule, Collecting Duct Deck (29):
% of filtered Na reabsorbed in the Loop of Henle?
Descending loop is permeable only to:
Osmolality of filtrate as it passes through descending, deep medullary, and ascending loop:
Which segment of loop is not permeable to water?
Membrane apparatus carrying solutes from collecting tubule lumen into cell in the Thick Ascending Limb?
What is the driving force of the NKCC pump?
What is the limiting factor in the NKCC pump?
% of the filtered Na reabsorbed in the Thick Ascending Loop?
Type of diuretic that acts on NKCC pump?
% of filtered Na reabsorbed in the Distal Tubule?
Is distal tuble permeable to water?
Pump of action in the distal tubule?
Na/Cl symporter....secondary active transport driven by Na
Genetic mutation of NaCl pump in distal tubule?
5 key features of Gitleman Syndrome:
1. Normal BP
2. Metabolic alkalosis
Drugs that manipulate NaCl channel in distal tubule?
First area with VARIABLE reabsorption of Na?
Two principle channel types in Principal cells of collecting tubules?
ENac's (epithelial Na channels)
ROMK's (renal outer medullary K channels)
Collecting duct permeability to water?
Primary mechanism of controlling salt reabsorption in principle cells?
**regulated by RAAS
3 primary signals stimulating renin release?
2. Decreased stretch in afferent arterioles
3. Decreased Cl delivery to macula densa
Where is renin released from?
Juxtaglomerular cells in the afferent arteriole
Clinical triggers for renin release:
2. low Na diet
3. low body NaCl
4. high SNS activity
4 primary actions of Angiotensin II:
1. stimulates aldosterone
2. systemic vasoconstriction
3. stimulates proximal tubule reabsorption of Na
4. Increases SNS activity
Why can aldosterone cross freely into cells?
What cell does aldosterone act on and what does it do there?
Principal cells of the collecting duct
-increases transcription of ENaCs, ROMKs, and Na-K-ATPase (basolateral membrane)
What does ROMK do?
Secretes K into collecting duct
% of filtered Na controlled by aldosterone:
can't shut off ENaCs --> increases BP