LP/Tumor Markes Flashcards
Get an A (22 cards)
Name a condition where elevated alpha fetoprotein is found
hepatoblastoma
What tumor marker is derived from epithelial cells of the fallopian tubes, endometrium, endocervix
CA-125
How many pts show test negative for CA-125 at time of dx
10-20%
What organization’s cancer guidelines do we follow in the US?
NCCN: national comprehensive cancer network
What benign diseases show elevated levels of CA-27.29?
breast, kidney, liver, ovarian cyst
What is CA-27.29 used for and what is it’s level of sensitivity?
It is used for screening and diagnosis and it lacks sensitivity
what is PSA’s sensitivity for prostate CA?
Its sensitivity is high
List the guidelines for screening for PSA:
USPSTF: against screening >75 yrs
ACS: say men should be a part of screening decision
screening guidelines: >50 yrs in men or >44 yrs in AA men with fhx of prostate CA
PSA+DRE+fhx=all done together to screen
Under what conditions should you offer a PSA test:
high risk pts
abnormal DRE
What type of PSA increase is predictive of prostate CA.
0.75 ng/mL per year
What are some benign conditions that show an increased PSA level?
BPH
prostatic trauma
What condition has elevated free PSA levels?
BPH
Will the fPSA/tPSA ratio be higher or lower in prostate CA?
lower
Is the PAP test sensitive but not specific?
yes
Where can PAP be found in
liver, RBC, bone marrow, platelets
What is the PAP test useful for?
monitoring the response to tx
Is a PAP test good on its own?
no, it’s beneficial when combined with the PSA test.
What is the calcitonin test used for?
to dx, monitor, and recurrence
When will CEA levels be elevated?
liver cancer, prostate CA, medullary thyroid CA
what happens to TG levels after a thyroidectomy?
levels will be low (< 2ng/mL) which means no recurrence
When testing CEA levels, what does a level of > 20 ng/mL mean
metastasis
What are some of the characteristics of a positive HER2/NEU test?
it occurs in 25-30% metastatic breast CA and it metastases very rapidly
