Lupus, Scleroderma, Sjogren's Syndrome, MCTD, and Spondyloarthropathies Flashcards Preview

Musculoskeletal/Rheumatic > Lupus, Scleroderma, Sjogren's Syndrome, MCTD, and Spondyloarthropathies > Flashcards

Flashcards in Lupus, Scleroderma, Sjogren's Syndrome, MCTD, and Spondyloarthropathies Deck (32):
1

HIgh risk races in SLE

African Americans, Hispanics, Asians

2

Susceptibility genes of SLE

HLA-DR2, complement deficiency

3

11 criteria for SLE

SOAPBRAINMD - Serositis, Oral ulcers, Arthritis, Photosensitivity, Blood disorders (cytopenias), Renal, ANA (FANA+), Immunologic (anti-Smith, anti-dsDNA, anti-phospholipid, anti-cardiolipin, lupus anticoagulant), Neuro (psychosis, seizures), Malar rash, Discoid rash

4

Significance of ANA in lupus

ANA is really sensitive, BUT NOT SPECIFIC (useful if high suspicion of lupus)

5

Where else do you see + ANA

Scleroderma

6

Anti dsDNA and anti-Sm antibodies

High specificity for lupus, anti-dsDNA associated with nephritis

7

Significance of anti-SSA and anti-SSB

Subcutaneous lupus, neonatal lupus, complete heart block in utero

8

Complement pathway in SLE

Both classical and alternative activated--consumes C3 and C4

9

Recurrent fetal loss in SLE is associated with what?

Antiphospholipid antibody

10

Major cause of mortality in SLE

Atherosclerosis of the coronary arteries

11

Criteria for antiphospholipid syndrome

Clinical event and persistent presence of antiphospholipid antibody

12

Antibodies in scleroderma

Topo 1 (diffuse), centromere (limited), PM/Scl, U1-RNP

13

Raynaud's phenomenon

Vasospastic attacks in digits (white to blue to red), can cause digital ulcers

14

Risk factors for sclerodermal renal crisis

Diffuse skin lesion, corticosteroids, anti-RNA polymerase III Ab

15

Most common organ involved in scleroderma

GI dismotility, upper GI tract dysfunction, lower GI (bad prognosis)

16

Lung diseases in scleroderma

Interstitial lung disease and pulmonary arterial hypertension

17

Lab findings in Sjogren's syndrome

ANA, SS-A/SS-B, rheumatoid factor

18

Signs and symptoms in Sjogren's syndrome

Dry eyes, dry mouth, dental caries, mouth ulcers, parotid/submandibular gland enlargement

19

Cancer risk in Sjogren's

Non-hodgkin's lymphoma

20

Mixed connective tissue disease overlaps with which diseases?

Overlap with lupus, scleroderma, and inflammatory mysoitis

21

Antibody in MCTD

U1-RNP

22

Common findings in MCTD

Puffy, swollen fingers (early), Raynaud's, Renal, and CNS involvment

23

Most common cause of death in MCTD

Pulmonary hypertension

24

Labs in spondyloarthropathies

Rheumatoid factor NEGATIVE, association with HLA-B27 (sensitive but not specific)

25

Common signs of spondyloarthropathies

Enthesitis, dactylitis (sausage digits),

26

Epidemiology of ankylosing spondylitis

Weird epidemiology - young, males>females

27

Clinical features of AS

Chronic back pain, symptoms worse in morning and IMPROVE with exercise

28

Joint involvement in AS

Hips, shoulders, knees, and ankles, dactylitis, enthesitis with heel pain

29

X-ray findings of AS

Squaring of vertebral bodies

30

Classic triad of reactive arthritis

Arthritis, conjunctivitis, urethritis

31

Psoraitic arthritis patterns

Oligoarticular (less than 4 joints, asymmetric), DIP involvement, axial involvement

32

Enteropathic arthritis

Occurs after GI disease; gut wall is leaky barrier, associated with Crohn's and ulcerative colitis