Lymphoid Neoplasms

Question 1

malignancy of lymphocytes
often form a mass
involve lymph nodes

Answer 1

lymphomas

Question 2

enlarged painless lymph nodes
fever, fatigue, chills, night sweats

Answer 2

lymphoma

Question 3

Reed Sternberg cells present on tissue biopsy

Answer 3

Hodgkin lymphoma

Question 4

derive from B cells
CD15 and CD30

Answer 4

Reed-sternberg cells
Hodgkin lymphoma

Question 5

malignant cell= Reed-Sternberg cell
B symptoms common
hypercalcemia (from macrophages)

Answer 5

Hodgkin lymphoma

Question 6

cervical lymphadenopathy commonly seen with this

Answer 6

Hodgkin Lymphoma

Question 7

Answer 7

Hodgkin lymphoma

Question 8

rare variant of Hodgkin lymphoma
malignant cells: LP (popcorn cells)
express CD20

Answer 8

Nodular Lymphocyte Predominant Hodgkin Lymphoma

Question 9

most common type of Hodgkin lymphoma
tumor forms fibrous tissue surrounding itself and creating nodules

Answer 9

Nodular Sclerosing Hodgkin Lymphoma

Question 10

more common in women
mediastinal mass on CXR
reed-sternberg cells seen in clear space (lacunar variant)

Answer 10

nodular sclerosing hodkgin lymphoma

Question 11

hodgkin lymphoma type with many different cells

Answer 11

Mixed Cellularity

Question 12

Lymphocyte rich type Hodgkin lymphoma has what prognosis

Answer 12

excellent

Question 13

Lymphocyte depleted Hodgkin lymphoma has what prognosis

Answer 13

poor

Question 14

localized; orderly spread from node to node

Answer 14

Hodgkin Lymphoma

Question 15

multiple peripheral sites
noncontiguous spread
extranodal involvement common

Answer 15

Non-Hodgkin lymphoma

Question 16

most common treatment for Hodgkin lymphoma

Answer 16

ABVD chemotherapy

Question 17

B and T cell malignancies (mostly B cells)
malignant cells obliterate lymph node architecture

Answer 17

Non-Hodgkin lymphoma

Question 18

most common Non-Hodgkin lymphoma
B cell malignancy (expresses CD19 and CD20)
median age of 64 yrs
AIDS defining malignancy

Answer 18

diffuse B cell lymphoma

Question 19

to treat diffuse B cell lymphoma

Answer 19

Rituximab (monoclonal CD20 antibody)

Question 20

B cell malignancy (express CD19, CD20)
t(14;18) translocation!!
overexpression of BCL2

Answer 20

follicular lymphoma

Question 21

median age 65 yrs
indolent course

Answer 21

follicular lymphoma

Question 22

lymphoma vs reactive lymphadenopathy

Answer 22

LAD will have macrophages b/c cell death
lymphoma will have BCL2 staining

Question 23

B cell malignancy
expresses CD5 and CD20
median age 68
poor prognosis

Answer 23

Mantle Cell Lymphoma

Question 24

t(11;14) translocation
overexpression of cyclin D1

Answer 24

mantle cell lymphoma

Question 25

____zone forms and expands in setting of chronic inflammation

Answer 25

marginal zone

Question 26

lymphoma in chronic inflammatory disorders

Answer 26

marginal zone lymphoma

Question 27

CD20 and CD5 negative for cyclin D1 lymphocyte count <5000

Answer 27

small lymphocytic lymphoma

Question 28

B cell malignancy very aggressive starry sky morphology EBV C-myc translocation

Answer 28

Burkitt's Lymphoma

Question 29

"starry sky"

Answer 29

Burkitts lymphoma

Question 30

endemic form: children and mass in mandible sporadic form: children and abdominal mass

Answer 30

Burkitt's lymphoma

Question 31

CD4+ T cell malignancy HTLV-1 infection skin lesions

Answer 31

T cell leukemia/lymphoma

Question 32

skin disorder of malignant T cells localized disease: Mycosis Fungoides diffuse disease: Sezary syndrome

Answer 32

Cutaneous T cell lymphoma

Question 33

Answer 33

Sezary cells (seen in cutaneous T cell lymphoma)