Flashcards in Lymphoid Organs Innate Immunte Deck (37):
what are the three groups of lymphoid organs?
sources of lymphocytes, sites of lymphocyte development (primary), sites where lymphocytes respond to antigens (secondary)
what are sources of lymphocytes?
yolk sac, fetal liver, bone marrow
sites of lymphocyte development (primary lymphoid organs)
thymus, bursa, peyer's patches, bone marrow
sites where lymphocytes respond to antigens (secondary lymphoid organs)
tonsils, spleen, lymph nodes, peyer's patches, bone marrow
what are the major lymphoid tissues?
thymus, bone marrow, spleen, lymph nodes, urogenital system, intestine, mammary glands, respiratory tract, salivary glands
primary lymphoid organs origin?
ectoendodermal junction or endoderm
secondary lymphoid organs origin?
primary lymphoid organs time of development?
early in embryonic life
secondary lymphoid organs time of development?
late in fetal life
primary lymphoid organs persistence?
involutes after puberty
secondary lymphoid organs persistence?
persists in adults
primary lymphoid organs effect of removal?
loss of lymphocytes
secondary lymphoid organs effect of removal?
no or minor effects
primary lymphoid organs response to antigen?
secondary lymphoid organs response to antigen?
examples of primary organs?
thymus, bursa, some Peyer patches
examples of secondary organs?
spleen, lymph nodes
lymphatics return what from the periphery to the heart and blood?
what are the filtering stations throughout the lymphatics?
what makes up the innate immunity?
physical barriers (skin, mucus membranes), humoral barriers (complement system), cellular barriers (phagocytic system, NK cells)
immediate response (0-4 hours)
infection->recognition by performed, non-specific and broadly specific effectors->removal of infectious agent
early induced innate response (4-96 hours)
infection->recognition of microbial-associated molecular patterns->inflammation recruitment and activation of effector cells->removal of infectious agent
adaptive immune response (>96 hours)
infection->transport of antigen to lymphoid organs->recognition by naive B and T cells->clonal expansion and differentiation to effector cells->removal of infectious agent
what happens in the absence of a normal flora?
the invading organisms face no competition and can readily colonize and invade surfaces
what activates the complement system?
PAMPs or Ag-Ab complex
what are the different pathways of complement activation?
classical pathway, alternative pathway, lectin pathway
which pathway(s) is antibody dependent (Ag-Ab)?
which pathway(s) is antibody Independent (no Ag-Ab)?
alternative pathway, lectin pathway
what is the first step of the complement pathway?
activation of C3 and generation of C5 convertase
what is activated after C3 and C5 convertase is generated?
what complex is formed from these pathways?
MAC-membrane attack complex
what are the receptors of the innate immune system?
pathogen-associated molecular patterns
microbe-associated molecular patterns
what immune system includes PAMPs and MAMPs recognition?
innate immune system
what are primary lymphoid organs?
sites of lymphocyte development