Lymphoid Organs Innate Immunte Flashcards Preview

PID > Lymphoid Organs Innate Immunte > Flashcards

Flashcards in Lymphoid Organs Innate Immunte Deck (37):
1

what are the three groups of lymphoid organs?

sources of lymphocytes, sites of lymphocyte development (primary), sites where lymphocytes respond to antigens (secondary)

2

what are sources of lymphocytes?

yolk sac, fetal liver, bone marrow

3

sites of lymphocyte development (primary lymphoid organs)

thymus, bursa, peyer's patches, bone marrow

4

sites where lymphocytes respond to antigens (secondary lymphoid organs)

tonsils, spleen, lymph nodes, peyer's patches, bone marrow

5

what are the major lymphoid tissues?

thymus, bone marrow, spleen, lymph nodes, urogenital system, intestine, mammary glands, respiratory tract, salivary glands

6

primary lymphoid organs origin?

ectoendodermal junction or endoderm

7

secondary lymphoid organs origin?

mesoderm

8

primary lymphoid organs time of development?

early in embryonic life

9

secondary lymphoid organs time of development?

late in fetal life

10

primary lymphoid organs persistence?

involutes after puberty

11

secondary lymphoid organs persistence?

persists in adults

12

primary lymphoid organs effect of removal?

loss of lymphocytes

13

secondary lymphoid organs effect of removal?

no or minor effects

14

primary lymphoid organs response to antigen?

unresponsive

15

secondary lymphoid organs response to antigen?

fully reactive

16

examples of primary organs?

thymus, bursa, some Peyer patches

17

examples of secondary organs?

spleen, lymph nodes

18

lymphatics return what from the periphery to the heart and blood?

extravascular fluid

19

what are the filtering stations throughout the lymphatics?

lymph nodes

20

what makes up the innate immunity?

physical barriers (skin, mucus membranes), humoral barriers (complement system), cellular barriers (phagocytic system, NK cells)

21

immediate response (0-4 hours)

infection->recognition by performed, non-specific and broadly specific effectors->removal of infectious agent

22

early induced innate response (4-96 hours)

infection->recognition of microbial-associated molecular patterns->inflammation recruitment and activation of effector cells->removal of infectious agent

23

adaptive immune response (>96 hours)

infection->transport of antigen to lymphoid organs->recognition by naive B and T cells->clonal expansion and differentiation to effector cells->removal of infectious agent

24

what happens in the absence of a normal flora?

the invading organisms face no competition and can readily colonize and invade surfaces

25

what activates the complement system?

PAMPs or Ag-Ab complex

26

what are the different pathways of complement activation?

classical pathway, alternative pathway, lectin pathway

27

which pathway(s) is antibody dependent (Ag-Ab)?

classical pathway

28

which pathway(s) is antibody Independent (no Ag-Ab)?

alternative pathway, lectin pathway

29

what is the first step of the complement pathway?

activation of C3 and generation of C5 convertase

30

what is activated after C3 and C5 convertase is generated?

C5

31

what complex is formed from these pathways?

MAC-membrane attack complex

32

what are the receptors of the innate immune system?

encoded germline

33

PAMPs

pathogen-associated molecular patterns

34

MAMPs

microbe-associated molecular patterns

35

what immune system includes PAMPs and MAMPs recognition?

innate immune system

36

what are primary lymphoid organs?

sites of lymphocyte development

37

what are secondary lymphoid organs?

sites where lymphocytes respond to antigens