Lymphoproliferative Disorders Flashcards
(7 cards)
What is Acute Lymphoblastic Leukaemia (ALL)
Uncommon, found in kids. Disorder of bone marrow cells (lymphid progenitors) “Limping child”
What is the presentation of Acute Lymphoblastic Leukaemia?
2/3 Week HIstory of bone marrow failure i.e. bone or joint pain
What are the characteristics of A.L.L. Cells?
In Blood: Large Cells B-Cells Express CD19 In Bone Marrow: Looks marrow is replaced by blast
What is CLL?
Technically not actually Leukaemia.
Due to their maturity, they resemble normal lymphocytes.
Requires a B Cell Count >5 for diagnosis
How common is CLL?
The commonest leukaemia worldwide.
2:1 M:F ratio
What symptoms suggest CLL? (4)
Often asymptomatic, but may present as:
- Bone Marrow Failure (Anaemia / Thrombocytopaenia)
- Lymphadenopathy
- Splenomegaly
- Fever and Sweat
What are the staging of CLL?
Binet Staging:
A, B, C
(C has anaemia or thrombocytopenia)
