Lymphoreticular REVIEW

Question 1

Eosinophilia be careful of [3]

Answer 1

Allergy
Parasite
CML

Question 2

Recall infectious mononucleosis

Answer 2

‘atypical’ lymphocytes by EBV, CMV
- polyclonal B cell expansion w heterophil AB

EBV Cx of Burkitt’s Lymphoma

Question 3

Raw oyster virus?

Answer 3

Hep A

Question 4

Follicular lymph found in what demographic

Answer 4

Not children

Question 5

CML translocation

Answer 5

t 9;22

Question 6

Follicular Lymphoma translocation

Answer 6

t 14;18

High BCL2 oncogene - inhibit apoptosis hence indolent

Question 7

Burkitt’s Lymphoma translocation

Answer 7

t 8;14
Upregulation of MYC gene - aggressive
EBV associated

Question 8

DLBCL associated w

Answer 8

EBV genome

also other viruses

Question 9

CMV what cancer

Answer 9

Not known to cause tumors

Question 10

HHV8

Answer 10

Kaposi’ Sarcoma associated HIV w AIDS

- lymphatic endothelium, purple lesions

Question 11

How does leukemia cause anemia and TCP

Answer 11

Suppression of normal hematopoiesis by leukemic clones

Question 12

Difference between aggressive and indolent cancers

Answer 12

Tend to be localized vs involve multiple nodule sites and organs

Question 13

EBV associated cancers

Answer 13

Burkitts
Gastric Carcinoma
NP carcinoma

Question 14

Hep B associated cancer

Answer 14

HCC

Question 15

HPV associated cancers

Answer 15

Squamous dysplasia, carcinoma, most common Cervix

Question 16

Reed-Sternberg Cells

Answer 16

Large cells w multiple nuclei or single nucleus w multiple nuclei lobes each w large inclusion like nucleolus
- prominent nucleolus
EBV can be associated

Question 17

Causes of Splenomegaly

and Cx

Answer 17

Infection
Anaemia, Marrow Damage (increase Extramedullary hematopoeisis)
Portal HT, Cirrhosis,
Lymphomas, Leukemias

Cytopenias due to sequestration

Question 18

Whats Thymomos associated w

Answer 18

Myasthenia Gravis