M12 Spirochaetes & ANUG Flashcards Preview

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Flashcards in M12 Spirochaetes & ANUG Deck (36):
1

what kind of cell wall does spirochetes have

gm -Ve cell wall
doesnt stain well

2

spirochetes are fastidious what does this mean

difficult to grow in lab on agar or broth

3

are spirochetes common in mouth

very common
assc with deep perio pockets
increase with periodontitis

4

what si struct of spirochetes

helical bac
central protoplasmic cyinder
3--5 axial filaments in outer cell envelope

5

what si the genus of spirochetes

Treponema
borrelia

6

what is borrelia burghdorferi

20 sub sp 5 cause disease

7

what is the disease borrelia burghdorferi cause

lymes disease

8

what is lames disease

tick bite - zoonotic
slow grow
microaerophilic spirochete

9

what is the primary infection of lames disease

red spot at bite site the enlarges withal area in middle
red ring

10

what are the symptoms of lymes disease

headache
drowsiness
mild fever
joint/muscle pain
swollen lymph nodes

11

when does he symptoms take effect

3-30 days post infection

12

what happens to 15% people after 1-5 weeks after a tick bite

neuro borrelia
- neurological implication

13

what are the symptoms of euro borrelia

back pain
numb feel at bite
meningits presntation
chornic
lyme arthritis
inflam heart

14

what does treponema palladium cause

csyphilus

15

what are the symptoms implications of csyphilus

painless chancre
rash
flu like symptoms
occasional rash
neuro and CV madness

16

what are the diffenret progressions of csyphilus and time

primary
- 3 days - 3 months

secondary
- 2 weeks - 24 months

latent
- 1-30 years

tertiary
- 1- greater than 30 years

17

what can congenital syphilus cause

vertical transmission mother to child
- saddle nose
- hutchisons teeth notched incisors

18

what is used to treat syphilus

penicillin
- 2 million unitsintramuscular Pen G
- 3 injections for latent syphiuls

19

where are oral treponemes

loose assc at edge sub gingival plaque

20

what are some oral treponemes

treponema vincentii
treponema denticola (red complex)
treponema oralis

21

what is T denticola

larger genome the T palladium
most proteolytic member of red complex
attach at to gingival fibroblast
induce cyttoxicty and cell death

22

what are the stress responses of t denticola

superoxide dimutase (SOD) activity
arginine deaminase

23

what sit he assc of t deneticola with p gingivalis

commonly found assc with each other in chronic perio lesions
congregate
grown in mixed biofilms

24

what does the relationship of t denticola and p gingivalis show

increasing evidence of synergistic assc between two periopathogens

25

what is AUG

acute (necrotising) ulcerative gingivitis
acute painful true infection of gingiva

26

what is AUG assc with

immunosuppression
- poor oral hygiene
- smoking
- malnutrition
- stress
- systemic illness

27

what causes AUG

a fuso-spirochaetal complex fusobac nucletum and treponema vincentii

28

what other microorg is present at AUG

prevotella intermedia
large numbers

29

what is the presentation of AUG

acute inflam red and shiny
bleeding
ulcers
lesions

30

what is vincents angina normally assc with

AUG

31

what is vin cents angina

infection pharynx
unilateral sore throat
increased intensity over several days
referred earache
bad taste in mouth
halitosis
deep ulcer in one tonsil

32

what does treponema vincentii do

spirochetes mix reuird
cell assc proteolytic enzymes
- prod trypsin like proteases
fusobacterium required for essential GF;s

33

what is the treatment of AUG

intensive local oral hygiene - ultrasonic scaler
oral hygiene advice and mouth rinses - chlorhexidine
short course Ab
- metronizadole
- 200mg fro 5 days

34

what is cancrum oris (NOMA)

severe form AUG
- children developing countries

35

what si the typical pt fro cancrum oris

malnourished
measles and leukmai history

36

what doe cancrum oris cause

gingival infections spread into the cheeks and face
extensive tissue loss and facial disfigurement