M6: Key Pharmacokinetic Properties of Antibiotics Flashcards Preview

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Flashcards in M6: Key Pharmacokinetic Properties of Antibiotics Deck (14)
1

Non-Renal Elimination (7)

Most antibiotics require dose adjustments in
renal insufficiency, except for these

Azithromycin
Beta-lactams (ceftriaxone, naf/ox)
Clindamycin
Moxifloxacin
Rifampin
Tetracyclines
Fidaxomicin

2

Elimination Dependent on Hepatic Function (6)

Require dose adjustment or close monitoring
in hepatic insufficiency

Tigecycline
Rifampin
Nafcillin/Oxacillin
Ceftriaxone
Metronidazole
Clindamycin

3

Good/Very Good Oral Absorption (10)

*Concurrent administration of di- and tri-valent cations decrease absorption (via chelation)

Clindamycin
Fluoroquinolones*
Linezolid
Metronidazole
Nitrofurantoin
Tetracyclines*
Rifampin
TMP/SMX
Beta-lactams (good)
Macrolides

4

Minimal Oral Absorption (4)

Aminoglycosides
Polymyxins
Vancomycin
Fidaxomicin

5

Wide Distribution (excellent CSF penetration) (4)

Metronidazole
Rifampin
TMP/SMX
Linezolid

6

Moderate Distribution (good CSF penetration) (9)

Vancomycin
Select Beta-lactams
-ceftriaxone
-cefuroxime
-ceftazidime
-cefepime
-imipenem
-meropenem
Fluoroquinolones

7

Poorly Distributed (4)
*(only for cystitis due to low systemic levels)

Aminoglycosides
Daptomycin
Polymyxins
Nitrofurantoin*

8

Azithromycin
Beta-lactams (ceftriaxone, naf/ox)
Clindamycin
Moxifloxacin
Rifampin
Tetracyclines
Fidaxomicin

Non-Renal Elimination (7)

Most antibiotics require dose adjustments in
renal insufficiency, except for these

9

Tigecycline
Rifampin
Nafcillin/Oxacillin
Ceftriaxone
Metronidazole
Clindamycin

Elimination Dependent on Hepatic Function (6)

Require dose adjustment or close monitoring
in hepatic insufficiency

10

Clindamycin
Fluoroquinolones*
Linezolid
Metronidazole
Nitrofurantoin
Tetracyclines*
Rifampin
TMP/SMX
Beta-lactams (good)
Macrolides

Good/Very Good Oral Absorption (10)

*Concurrent administration of di- and tri-valent cations decrease absorption (via chelation)

11

Aminoglycosides
Polymyxins
Vancomycin
Fidaxomicin

Minimal Oral Absorption (4)

12

Metronidazole
Rifampin
TMP/SMX
Linezolid

Wide Distribution (excellent CSF penetration) (4)

13

Vancomycin
Select Beta-lactams
-ceftriaxone
-cefuroxime
-ceftazidime
-cefepime
-imipenem
-meropenem
Fluoroquinolones

Moderate Distribution (good CSF penetration) (9)

14

Aminoglycosides
Daptomycin
Polymyxins
Nitrofurantoin*

Poorly Distributed (4)
*(only for cystitis due to low systemic levels)