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Flashcards in mAB cancer Deck (40)
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1

example of CD antigen

alemtuzumab

2

examples of vascular endothelial growth factor inhibitor

bevacizumab

3

examples of epidermal growth factor receptor inhibto

trastuzumab

4

immune checkpoint inhibitor example

nivolumab

5

two hit hypothesis

activation of oncogene
inactivation of tumor supreesion gene

6

multihit hypothesis

10 hallmarks of cancer

7

3 hallmarks that we are targeting

proliferating signals with EGFR inhibitors
immune destruction avoidance - anti CTLA4 antibodies
angiogenesis - VEGF signalling inhibitors

8

3 mechanisms of antibody in cancer

direct tumor cell killing
vascualr and stromal cell ablation
immune mediated tumor cell killing

9

whats is trastuzumab indicated in

ERBB2 postive breast cancer single agent if had previous cehmo, in combo with paclitaxel if not
or gastric or gastro esophageal junction carcinnoma in combo with 5FU if have not recieved prior treatment for metastatic disease

10

what is bevacizumab indicated in

kidney metastasis
glioblastoma
colon metastasis
non small cell liver cancer

11

what is alemtuzumab indicated in

single agent for B cell chronic lymphocytic leukemia

12

what are the cluster of differentiation cell s

protocol used for the identification and association of cell surface molecules on leukocytes
can act as receptors or ligands

13

what is CD52

a glycoprotein that is not shed or internalized making it a good target
highly expressed in certain cancer - chronic lymphocytic leukemia

14

how does alemtuzumab work

binds to CD52 antigenic sites and sitmulates cross linking by antibodies
complement dependent cytotoxicity and direct cellular apoptosis via natural killer activity

15

describe the use of VEGF in cancer cells

as the tumor grows the inside becomes hypoxic so they need angiogenic growth factors to get blood supply in the tumors
one of the most potent growth factors
induces neovascularization for malignant cells in an autocrine fashion
levels of VEGF in the blood correlate with poor prognosis and recurrence

16

bevacizumab is produced by

ovarian cells of chinese hamster in a gentamicin** containing nutrient medium

17

bevacizumabdoesnt attack tumor cells it ____ them

starves

18

bevacizumab is cytotoxic and cytotaic

true

19

bevacizumabMOA

block VEGF

20

preparation of bevacizumab infusion

with 0,9% normal saline up to volume of 100mL
not dextrose

21

main 3 side effects of bevacizumb

GI perforation
surgery and wound healing complications
hemorrhage

22

what is EGFR and HER1/2

transmebrane glycoproteins in epithelial cells
involved in normal cell growth and differentiation

23

what protein is overexpressed in metastatic breast cancer that correlates with poor prognosis

HER2

24

trastuzumab MOA

seletively binds with extracellular domain of HER2 receptor

25

what happens after blocker HER2 receptor

inhibit angiogenesis
enhance apoptosis
inhibit cell proliferation
inhibit migration andand invasion

26

2 ways to diagnosis HER2 postive breast cancer

immunohistochemistry
fluorescence in situ hybridization

27

describe immunohistochemistry test ***

most commonly used
determine amount of HER2 receptor protein on cancer cell surface

28

explain the IHC test scaling

scale of 0-3
if get 0-1 then tumor is HER2-
if get +3 its HER2+
if get +2 you have to do the FISH test

29

describe the FISH test ****

determine if there is a normal number of HER2+ in the tumor
compares the amount of HER2 genes with the number of normal genes in the tumor cell
more accurate

30

the tumor is HER2+ in FISH test if

there are 2 or more HER2 genes for every 1 normal gene