Macitentan (Opsumit) Flashcards Preview

1 - - Lexicomp Cardiology Monograph > Macitentan (Opsumit) > Flashcards

Flashcards in Macitentan (Opsumit) Deck (4)
Loading flashcards...
1

What is the initial and maximum dose of macitentan (Opsumit)? (Lexi)

1. Initial 10 mg once daily
2. Maximum 10 mg once daily

2

What are the frequent adverse reactions (>10%) associated with macitentan (Opsumit)? (Lexi)

1. CNS = Headache (14%)
2. Hematologic = Anemia (13%)
3. Respiratory = Nasopharyngitis (<20%), pharyngitis (<20%), bronchitis (12%)

3

What is the mechanism of action of macitentan (Opsumit)? (Lexi)

Blocks endothelin (ET)-1 from binding to endothelin subtypes ETa and ETb

4

What is the half-life for macitentan (Opsumit)? (Lexi)

1. 16 hours
2. 48 hours (active metabolite)