main concept Flashcards

1
Q

What electrolytes does the low volume state have?

Total Na, serum Na, Ca, Cl, K

A

high total Na,
low serum Na (dilutional effect)
low Ca2+(bound to Albumin)
low Cl
low K
Low H(alkaline)

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2
Q

What pH does the low volume state have?

A

Alkalotic (except diarrhea, RTA Type II, and DKA) b/c Aldo dumps H+

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3
Q

What pH do vomiters have?

A

Alkalotic b/c you vomit out H+;low volume state

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4
Q

What pH does diarrhea have?

A

Acidosis b/c stool has bicarb from pancreas

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5
Q

What happened if pulse increase >10 on standing

A

Hypovolemic shock

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6
Q

What happened if pulse increase <5 on standing?

A

Autonomic dysfunction

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7
Q

What pump stops working in an energy state?

A

NA/K pump due to loss of ATP and Mitochondria dysfunction

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8
Q

symptoms of a low energy state in the heart?

A

CV: heart failure, pericardial effusion

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9
Q

symptoms of a low energy state in the Bone marrow?

A

Bone marrow: suppressed pancytopenia

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10
Q

symptoms of a low energy state in the vessels?

A

Vascular endothelium: breaks down; vasculitis

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11
Q

symptoms of a low energy state in the Lungs?

A

Lungs: infection, SOB

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12
Q

symptoms of a low energy state in the Kidney, GI and bladder?

A

Kidney: PCT stops working (electrolytes imbalance)
GI: N/V/D
Bladder: urinary retention

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13
Q

symptoms of a low energy state in the Sperm count, Breast, endometrium and Germ Cells?

A

Sperm: decreased
Germ cells: predisposed to cancer
Breasts: atrophic
Endometrium: amenorrhea; atrophic

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14
Q

symptoms of a low energy state in the muscle?

A

Muscle: weakness, SOB, vasodilation, urinary retention, constipation

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15
Q

symptoms of a low energy state in the skin, hair, nail/cuticles?

A

Rapidly Dividing Cells:
Skin: dry
Cuticles: brittle nails
Hair: alopecia

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16
Q

What are the most common signs of the low energy state?

A

Tachypnea and dyspnea

17
Q

What are the most common symptoms of the low energy state?

A

Weakness and SOB

18
Q

What is the most common cause of death in the low energy state

19
Q

Explain all restrictive lung diseases

A

Restrictive: interstitial problem (non-bacterial)

20
Q

Explain all obstructive lung diseases

A

Obstructive: airway problem (bacterial)
Big mucus-filled lungs (high RV, high Reid)

index = thickness/ airway lumen)

21
Q

What symptoms does a “more likely to depolarize” state have?

A

Brain: psychosis, seizures, jitteriness Skeletal muscle: muscle spasms, cramps
SM: diarrhea
Cardiac: tachycardia, arrhythmia

22
Q

What symptoms does a “less likely to depolarize” state have?

A

Brain: lethargy, mental status changes, depression Skeletal muscle: weakness, SOB
SM: constipation
Cardiac: hypotension, bradycardia

23
Q

What is the humoral immune response?

A

B cells and PMNs patrol the blood looking for bacteria

24
Q

What is the cell-mediated immune response?

A

T cells and Macrophages patrol the tissues looking for non-bacteria

25
What are macrophages called in each area of the body?
Blood = Monocytes Brain = Microglia Lung = T1 pneumocytes Liver = Kupffer cells Spleen = RES cells Lymph = Dendritic cells Kidney = Mesangial cells Payers patches = M cells Skin = Langerhans cells Bone = Osteoclasts CT: Histiocytes Giant cells Epitheloid cells
26
What is the CBC for every vasculitis?
low RBC, platelets, high WBC, T cells, MP, ESR schistocytes
27
What is the time course of the inflammatory response?
1 hr: Swelling Day 1: PMNs show up at 4 ½ hours, predominate at 24 hours Day 3: PMNs peak Day 4: MP/T cells shows up Day 7: MP/T cells peak, Fibroblasts arrive Day 30: Fibroblasts peak Month 3-6: Fibroblasts complete fibrosis
28
What state does estrogen mimic
The neuromuscular dz state (estrogen is a muscle relaxant)
29
What does high GABA levels lead to?
Bradycardia, lethargy, constipation, impotence, and memory loss
30
What is Necrosis?
Non-programmed cell death = noisy, inflammation, nucleus destroyed first
31
What is Apoptosis?
Programmed cell death = quiet, no inflammation, nucleus guides it =>
32
What is Apoptosis?
Programmed cell death = quiet, no inflammation, nucleus guides it =>
33
What is Pyknosis?
Nucleus turns into blobs "pink blobs"
34
What is Pyknosis?
Nucleus turns into blobs "pick blobs"
35
What is Karyohexxis?
Nucleus fragments
36
What is Karyolysis?
Nucleus dissolves
37
patient with dementia, tremor, fatigue....rule out
hyperthyroidism with TSH test